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Article
Open AccessHX009, a novel BsAb dual targeting PD1 x CD47, demonstrates potent anti-lymphoma activity in preclinical models
Both PD1/PD-L1 and CD47 blockades have demonstrated limited activity in most subtypes of NHL save NK/T-cell lymphoma. The hemotoxicity with anti-CD47 agents in the clinic has been speculated to account for the...
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Article
Open AccessDistinct genomic landscape of Chinese pediatric acute myeloid leukemia impacts clinical risk classification
Studies have revealed key genomic aberrations in pediatric acute myeloid leukemia (AML) based on Western populations. It is unknown to what extent the current genomic findings represent populations with differ...
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Article
Open AccessDifferent syngeneic tumors show distinctive intrinsic tumor-immunity and mechanisms of actions (MOA) of anti-PD-1 treatment
Cancers are immunologically heterogeneous. A range of immunotherapies target abnormal tumor immunity via different mechanisms of actions (MOAs), particularly various tumor-infiltrate leukocytes (TILs). We mode...
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Article
Open AccessAdenosine-related small molecules show utility of recall antigen assay to screen compounds for off-target effects on memory T cells
Extracellular adenosine suppresses T cell immunity in the tumor microenvironment and in vitro treatment of memory T cells with adenosine can suppress antigen-mediated memory T cell expansion. We describe utili...
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Article
Open AccessThe design, analysis and application of mouse clinical trials in oncology drug development
Mouse clinical trials (MCTs) are becoming wildly used in pre-clinical oncology drug development, but a statistical framework is yet to be developed. In this study, we establish such as framework and provide ge...
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Article
De novo design of a fluorescence-activating β-barrel
The regular arrangements of β-strands around a central axis in β-barrels and of α-helices in coiled coils contrast with the irregular tertiary structures of most globular proteins, and have fascinated structur...
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Article
Guiding automated NMR structure determination using a global optimization metric, the NMR DP score
ASDP is an automated NMR NOE assignment program. It uses a distinct bottom-up topology-constrained network anchoring approach for NOE interpretation, with 2D, 3D and/or 4D NOESY peak list...
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Article
PDBStat: a universal restraint converter and restraint analysis software package for protein NMR
The heterogeneous array of software tools used in the process of protein NMR structure determination presents organizational challenges in the structure determination and validation processes, and creates a le...
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Article
Segmental isotope labeling of proteins for NMR structural study using a protein S tag for higher expression and solubility
A common obstacle to NMR studies of proteins is sample preparation. In many cases, proteins targeted for NMR studies are poorly expressed and/or expressed in insoluble forms. Here, we describe a novel approach...
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Article
CASD-NMR: critical assessment of automated structure determination by NMR
