40 Result(s)
within
Bin-Bin **
Science, Humanities and Social Sciences, multidisciplinary
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessRegulation of T cell proliferation by JMJD6 and PDGF-BB during chronic hepatitis B infection
T cell functional exhaustion during chronic hepatitis B virus (HBV) infection may contribute to the failed viral clearance; however, the underlying molecular mechanisms remain largely unknown. Here we demonstr...
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Open AccessRegulation of T cell function by microRNA-720
Chronic hepatitis B virus (HBV) infection is a major global health burden. Functional exhaustion and numerical reduction of HBV-specific cytotoxic T lymphocytes (CTLs) in the liver and peripheral blood limit a...
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Open AccessFluoxetine regulates mTOR signalling in a region-dependent manner in depression-like mice
Previous studies have demonstrated that the mammalian target of rapamycin (mTOR) signaling pathway has an important role in ketamine-induced, rapid antidepressant effects despite the acute administration of fl...
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Open AccessLovastatin blocks Kv1.3 channel in human T cells: a new mechanism to explain its immunomodulatory properties
Lovastatin is a member of Statins, which are beneficial in a lot of immunologic cardiovascular diseases and T cell-mediated autoimmune diseases. Kv1.3 channel plays important roles in the activation and prolif...
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Open AccessCorrection: Corrigendum: Lovastatin blocks Kv1.3 channel in human T cells: a new mechanism to explain its immunomodulatory properties
Scientific Reports 5: Article number: 17381; published online: 30 November 2015; updated: 10 March 2016 This Article contains errors in Figure 3 and Figure 7a. In Figure 3A, 3B, 3C, 3D and 3E the current label...
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Open AccessMild decrease in TBX20 promoter activity is a potentially protective factor against congenital heart defects in the Han Chinese population
Congenital heart defects (CHDs) are one of the most common human birth defects worldwide. TBX20 is a crucial transcription factor for the development of embryonic cardiovascular system. Previous studies have d...
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Open AccessDramatically decreased magnetoresistance in non-stoichiometric WTe2 crystals
Recently, the layered semimetal WTe2 has attracted renewed interest owing to the observation of a non-saturating and giant positive magnetoresistance (~105%), which can be useful for magnetic memory and spintroni...
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Superconductivity at 7.8 K in the ternary LaRu2As2 compound
Here we report the discovery of superconductivity in the ternary LaRu2As2 compound. The polycrystalline LaRu2As2 samples were synthesized by the conventional solid state reaction method. Powder X-ray diffraction ...
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Open AccessPotentials of the elevated circulating miR-185 level as a biomarker for early diagnosis of HBV-related liver fibrosis
Early diagnosis of liver fibrosis is critical for early intervention and prognosis of various chronic liver diseases. Conventional repeated histological assessment is impractical due to the associated invasive...
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Open AccessGenetic association between TNF-α −857 C/T polymorphism and ankylosing spondylitis susceptibility: evidence from a meta-analysis
Certain studies have suggested that the tumor necrosis factor-α (TNF-α) −857 C/T polymorphism is associated with risk of ankylosing spondylitis. However, the conclusions remain controversial. Therefore, we per...
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Article
Open AccessRNA-binding protein RBM3 prevents NO-induced apoptosis in human neuroblastoma cells by modulating p38 signaling and miR-143
Nitric oxide (NO)-induced apoptosis in neurons is an important cause of neurodegenerative disease in humans. The cold-inducible protein RBM3 mediates the protective effects of cooling on apoptosis induced by v...
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Article
Open AccessSignificant survival benefit of adjuvant chemotherapy after concurrent chemoradiotherapy in locally advanced high-risk nasopharyngeal carcinoma
The present study aimed to define high-risk patients who may benefit from additional adjuvant chemotherapy (AC) after concurrent chemotherapy in combination with intensity-modulated radiotherapy among patients...
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Open AccessBlockage of transient receptor potential vanilloid 4 alleviates myocardial ischemia/reperfusion injury in mice
Transient receptor potential vanilloid 4 (TRPV4) is a Ca2+-permeable nonselective cation channel and can be activated during ischemia/reperfusion (I/R). This study tested whether blockade of TRPV4 can alleviate m...
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Article
Open AccessExpression profiling of TRIM protein family in THP1-derived macrophages following TLR stimulation
Activated macrophages play an important role in many inflammatory diseases including septic shock and atherosclerosis. However, the molecular mechanisms limiting macrophage activation are not completely unders...
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Open AccessUnusual Anti-allergic Diterpenoids from the Marine Sponge Hippospongia lachne
Hipposponlachnins A (1) and B (2), possessing an unprecedented tetracyclo [9.3.0.02,8.03,7] tetradecane ring system, and the probable biogenetic precursor [3, (1R*,2E,4R*,7E,10S*,11S*,12R*)-10, 18-diacetoxydolabe...
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Open AccessComposition and temperature-dependent phase transition in miscible Mo1−xWxTe2 single crystals
Transition metal dichalcogenides (TMDs) WTe2 and MoTe2 with orthorhombic Td phase, being potential candidates as type-II Weyl semimetals, are attracted much attention recently. Here we synthesized a series of mis...
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Open AccessNitrogen Starvation Impacts the Photosynthetic Performance of Porphyridium cruentum as Revealed by Chlorophyll a Fluorescence
Nitrogen is one of the most important nutrients needed for plants and algae to survive, and the photosynthetic ability of algae is related to nitrogen abundance. Red algae are unique photosynthetic eukaryotic ...
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Open AccessDysivillosins A–D, Unusual Anti-allergic Meroterpenoids from the Marine Sponge Dysidea villosa
Four unusual meroterpenoids, dysivillosins A–D (1–4), were isolated from an organic extract of the marine sponge Dysidea villosa collected from the South China Sea. Their planar structures were determined by 1D a...
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Article
Open AccessRelease and Degradation of Microencapsulated Spinosad and Emamectin Benzoate
The dynamics of release and degradation of the microencapsulation formulation containing spinosad (SP) and emamectin benzoate (EM) were evaluated in the present study. SP and EM were microencapsulated using bi...
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Open AccessTotal morphosynthesis of biomimetic prismatic-type CaCO3 thin films
Biomimetic mineralization can lead to advanced crystalline composites with common chemicals under ambient conditions. An exceptional example is biomimetic nacre with its superior fracture toughness. The synthe...
