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Article
Low-density neutrophils in hidradenitis suppurativa: insights from immunophenoty** and activation markers
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Article
Shared and distinct genetics of pure type 1 diabetes and type 1 diabetes with celiac disease, homology in their auto-antigens and immune dysregulation states: a study from North India
This study was undertaken to explicate the shared and distinctive genetic susceptibility and immune dysfunction in patients with T1D alone and T1D with CD (T1D + CD).
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Article
An Indian Family with Autosomal Dominant Hyper-IgE Syndrome Due to IL6ST Defect
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Article
Diminished PD-L1 regulation along with dysregulated T lymphocyte subsets and chemokine in ANCA-associated vasculitis
ANCA-associated vasculitis (AAV) is a life-threatening disease characterized by small vessel inflammation and pathogenic self-directed antibodies. Programmed death-ligand 1 receptor (PD-1) and programmed cell ...
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Article
Pediatric systemic lupus erythematosus: phagocytic defect and oxidase activity of neutrophils
There are limited data on neutrophil function in pediatric-onset systemic lupus erythematosus (pSLE) patients. This study aimed to evaluate phagocytosis and oxidase activity of neutrophils in patients with pSLE.
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Article
Open AccessGenetic abnormality of cytochrome-P2C9*3 allele predisposes to epilepsy and phenytoin-induced adverse drug reactions: genoty** findings of cytochrome-alleles in the North Indian population
This research aims to study the association of genetic polymorphism in genes coding for CYP2C9 and CYP2C19 in phenytoin-induced dose-related toxicity and to assess if the presence of allele CYP2C9*3 plays a ro...
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Article
Mystery of a Family with Recurrent Male Infant Deaths- Solved by Autopsy and Molecular Tests
The authors report a case of a six weeks old boy who presented with acute febrile illness and progressive abdominal distension. There was a significant family history of early male sibling deaths. Autopsy show...
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Article
Metabolic Syndrome and Its Effects on Cartilage Degeneration vs Regeneration: A Pilot Study Using Osteoarthritis Biomarkers
Osteoarthritis (OA) of the knee is one of the leading causes of disability characterized by degeneration of hyaline cartilage combined with reparative processes. Its strong association with metabolic syndrome...
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Article
Monoclonal Gammopathy of Unclear Significance in a Child with Wiskott-Aldrich Syndrome: a Rare Occurrence
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Article
A mechanistic approach to explore the neuroprotective potential of zonisamide in seizures
Epilepsy, a disease of the brain, is one of the most common serious neurological conditions. It is associated with a group of processes which alter energy metabolism, interrupt cellular ionic homeostasis, caus...
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Article
Allo-specific immune response profiles indicative of acute rejection in kidney allografts using an in vitro lymphocyte culture-based model
Ability to predict the manner in which a recipient’s immune system would respond to a transplanted graft by analyzing cytokine profiles of the “allograft antigen sensitized” recipient lymphocytes in vitro migh...
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Novel Mutation in SH2 Domain of STAT3 (p.M660T) in Hyper-IgE Syndrome with Sterno-Clavicular and Paravertebral Abscesses
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Article
Open AccessProceedings of the 23rd Paediatric Rheumatology European Society Congress: part one
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Article
TH17 Cells in STAT3 Related Hyper-IgE Syndrome
To assess the utility of T helper17 (TH17) cell enumeration vis-à-vis National Institutes of Health (NIH) scoring in Hyper IgE syndrome (HIES).
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Article
Common Variable Immunodeficiency
Common variable immunodeficiency (CVID) is the most common primary immunodeficiency of young adolescents and adults which also affects the children. The disease remains largely under-diagnosed in India and Sou...
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Article
Ataxia Telangiectasia Masquerading as Hyper IgM Syndrome
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Autoantibodies and their Judicious Use in Pediatric Rheumatology Practice
Autoantibody testing forms an important part of diagnostic workup of patients in Pediatric rheumatology practice. However it is important to understand that the mere presence of autoantibodies does not necessa...
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Article
Isolated Immunoglobulin G4 Subclass Deficiency in a Child with Bronchiectasis
Immunoglobulin G4 subclass deficiency is the most common IgG subclass deficiency, followed by immunoglobulin G2 deficiency. However, IgG2 deficiency is the most common IgG subclass deficiency associated with r...
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Article
Hemorrhagic Bullous Lesions in a Girl with Henoch Schönlein Purpura
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Chronic Granulomatous Disease: Two Decades of Experience From a Tertiary Care Centre in North West India
Chronic granulomatous disease (CGD) results from an inherited defect in the phagocytic cells of the immune system. It is a genetically heterogenous disease caused by defects in one of the five major subunits o...
