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Article

Amino acid-linked platinum(II) compounds: non-canonical nucleoside preferences and influence on glycosidic bond stabilities

Nucleobases serve as ideal targets where drugs bind and exert their anticancer activities. Cisplatin (cisPt) preferentially coordinates to 2′-deoxyguanosine (dGuo) residues within DNA. The dGuo adducts that ar...

Bett Kimutai, C. C. He, Andrew Roberts… in JBIC Journal of Biological Inorganic Chemi… (2019)