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  1. No Access

    Article

    Precise genomic deletions using paired prime editing

    Current methods to delete genomic sequences are based on clustered regularly interspaced short palindromic repeats (CRISPR)–Cas9 and pairs of single-guide RNAs (sgRNAs), but can be inefficient and imprecise, w...

    Junhong Choi, Wei Chen, Chase C. Suiter, Choli Lee… in Nature Biotechnology (2022)

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    Article

    Multiplex assessment of protein variant abundance by massively parallel sequencing

    Determining the pathogenicity of genetic variants is a critical challenge, and functional assessment is often the only option. Experimentally characterizing millions of possible missense variants in thousands ...

    Kenneth A. Matreyek, Lea M. Starita, Jason J. Stephany, Beth Martin… in Nature Genetics (2018)