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Article
Open AccessA reply to ‘Alteration of steroidogenesis in boys with autism spectrum disorders’
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Article
Dimerization of LOV domains of Rhodobacter sphaeroides (RsLOV) studied with FRET and stopped-flow experiments
The bacterium Rhodobacter sphaeroides has a short LOV (light-oxygen-voltage) domain, which is not connected to an effector domain but has an α-helix extension at the N-terminus as well as a helix-turn-helix (HTH)...
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Article
Open AccessElectron transfer pathways in a light, oxygen, voltage (LOV) protein devoid of the photoactive cysteine
Blue-light absorption by the flavin chromophore in light, oxygen, voltage (LOV) photoreceptors triggers photochemical reactions that lead to the formation of a flavin-cysteine adduct. While it has long been as...
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Article
Open AccessGestation-specific reference intervals for comprehensive spot urinary steroid hormone metabolite analysis in normal singleton pregnancy and 6 weeks postpartum
Normal pregnancy depends on pronounced adaptations in steroid hormone concentrations. Although in recent years, the understanding of these hormones in pregnancy has improved, the interpretation is hampered by ...
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Article
Open AccessA search for radical intermediates in the photocycle of LOV domains
LOV domains are the light sensitive parts of phototropins and many other light-activated enzymes that regulate the response to blue light in plants and algae as well as some fungi and bacteria. Unlike all othe...
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Chapter
Urinary Hormone Analysis in Acne
The analysis of urinary steroid hormone metabolites allows to detect multiple endocrinopathies involved in the evolution of acne. The word “profile,” introduced in the mid-1960s represents a multicomponent chr...
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Article
Setup and performance of a streak camera apparatus for transient absorption measurements in the ns to ms range
We describe the setup and performance of an apparatus for simultaneous time- and spectrally resolved measurements of transient absorption. The key component in this apparatus is a streak camera, yielding, for ...
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Article
Signals of LOV1: a computer simulation study on the wildtype LOV1-domain of Chlamydomonas reinhardtii and its mutants
Phototropins are photoreceptors regulating the blue-light response in plants and bacteria. They consist of two LOV (light oxygen voltage sensitive) domains each containing a non-covalently bound flavin-mononuc...
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Article
Effect of computational methodology on the conformational dynamics of the protein photosensor LOV1 from Chlamydomonas reinhardtii
LOV domains are the light-sensitive protein domains of plant phototropins and bacteria. They photochemically form a covalent bond between a flavin mononucleotide (FMN) chromophore and a cysteine, attached to t...
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Article
Mechanism of signal transduction of the LOV2-Jα photosensor from Avena sativa
Fusion proteins containing blue-light-activable protein domains possess great potential as molecular switches in cell signalling. This has recently been impressively demonstrated by connecting the light oxygen...
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Article
Prematurity Is Related to High Placental Cortisol in Preeclampsia
Fetal growth is compromised in animal models with high cortisol availability. In healthy pregnancies, the fetus is protected from high circulating cortisol levels by the placental 11β-hydroxysteroid dehydrogen...
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Article
TheT 1 state ofp-nitroaniline and related molecules: A CNDO/S study
The nature of the lowest energy triplet state (T 1) ofp-nitroaniline (PNA), N,N-dimethyl-p-nitroaniline (DMPNA) and nitrobenzene (NB) is reexamined using the semiempirical CNDO/S-CI method with selected parameter...
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Article
Calculation of transition metal compounds using an extension of the CNDO-formalism
A recently developed extension of the CNDO-method is used to study the electronic structure of a number of binuclear transition metal carbonyls and carboxylates with fourfold or quasi-fourfold symmetry. The re...
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Article
Two-photon spectroscopy of dipole-forbidden transitions
We have investigated the applicability of CNDO/S-type methods for the calculation of optical spectra of molecules with the special implication that the calculations should not only describe the intense, dipole...
