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  1. Article

    Open Access

    An open-label study to assess the feasibility and tolerability of rilmenidine for the treatment of Huntington’s disease

    Preclinical data have shown that rilmenidine can regulate autophagy in models of Huntington’s disease (HD), providing a potential route to alter the disease course in patients. Consequently, a 2-year open-labe...

    Benjamin R. Underwood, Zeyn W. Green-Thompson, Peter J. Pugh… in Journal of Neurology (2017)

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  2. No Access

    Article

    Spinocerebellar ataxias caused by polyglutamine expansions: A review of therapeutic strategies

    Six of the spinocerebellar ataxias (SCAs) are caused by expanded CAG trinucleotide repeats encoding polyglutamine tracts in different genes. Together with three other neurodegenerative diseases they represent ...

    Benjamin R. Underwood, David C. Rubinsztein in The Cerebellum (2008)