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Article
Genetic structure and environmental niche modeling confirm two evolutionary and conservation units within the western spadefoot (Spea hammondii)
The western spadefoot (Spea hammondii) is a Species of Special Concern in California and is now under review by the U.S. Fish and Wildlife Service for listing under the Endangered Species Act. We delineated poten...
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Article
Open AccessMechanistic Insights into the Cholesterol-dependent Binding of Perfringolysin O-based Probes and Cell Membranes
Cholesterol distribution in the cell is maintained by both vesicular and non-vesicular sterol transport. Non-vesicular transport is mediated by the interaction of membrane-embedded cholesterol and water-solubl...
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Chapter
Perfringolysin O Structure and Mechanism of Pore Formation as a Paradigm for Cholesterol-Dependent Cytolysins
Cholesterol-dependent cytolysins (CDCs) constitute a family of pore forming toxins secreted by Gram-positive bacteria. These toxins form transmembrane pores by inserting a large β-barrel into cholesterol-conta...
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Article
Open AccessEffective population size is strongly correlated with breeding pond size in the endangered California tiger salamander, Ambystoma californiense
Maintaining genetic diversity and population viability in endangered and threatened species is a primary concern of conservation biology. Genetic diversity depends on population connectivity and effective popu...
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Chapter
The Cholesterol-Dependent Cytolysin Family of Gram-Positive Bacterial Toxins
The cholesterol-dependent cytolysins (CDCs) are a family of β-barrel pore-forming toxins secreted by Gram-positive bacteria. These toxins are produced as water-soluble monomeric proteins that after binding to ...
