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Article
Open AccessRare X-linked variants carry predominantly male risk in autism, Tourette syndrome, and ADHD
Autism spectrum disorder (ASD), Tourette syndrome (TS), and attention-deficit/hyperactivity disorder (ADHD) display strong male sex bias, due to a combination of genetic and biological factors, as well as sele...
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Article
Open AccessPhysical Activity Preferences of People Living with Brain Injury: Formative Qualitative Research to Develop a Discrete Choice Experiment
The World Health Organization physical activity guidelines for people living with disability do not consider the needs of people living with moderate-to-severe traumatic brain injury. This paper describes the ...
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Article
Open AccessEconomic evaluation of physical activity mass media campaigns across the globe: a systematic review
Physical activity mass media campaigns can deliver physical activity messages to many people, but it remains unclear whether they offer good value for money. We aimed to investigate the cost-effectiveness, cos...
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Article
Open AccessImpact of physical activity programs and services for older adults: a rapid review
Knowledge of which physical activity programs are most effective for older adults in different sub-populations and contexts is limited. The objectives of this rapid review were to: 1) Overview evidence evaluat...
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Article
Genomics, convergent neuroscience and progress in understanding autism spectrum disorder
More than a hundred genes have been identified that, when disrupted, impart large risk for autism spectrum disorder (ASD). Current knowledge about the encoded proteins — although incomplete — points to a very ...
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Article
Open AccessLeveraging large genomic datasets to illuminate the pathobiology of autism spectrum disorders
“Big data” approaches in the form of large-scale human genomic studies have led to striking advances in autism spectrum disorder (ASD) genetics. Similar to many other psychiatric syndromes, advances in genotyp...
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Article
Open AccessHOXC8 regulates self-renewal, differentiation and transformation of breast cancer stem cells
Homeobox genes are master regulators of cell fate during embryonic development and their expression is altered in cancer. By regulating the balance between cell proliferation and differentiation, they maintain...
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Article
A potential molecular mechanism for hypersensitivity caused by formalin-inactivated vaccines
Heat, oxidation and exposure to aldehydes create reactive carbonyl groups on proteins, targeting antigens to scavenger receptors. Formaldehyde is widely used in making vaccines, but has been associated with at...
