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    Article

    Helios is a key transcriptional regulator of outer hair cell maturation

    The sensory cells that are responsible for hearing include the cochlear inner hair cells (IHCs) and outer hair cells (OHCs), with the OHCs being necessary for sound sensitivity and tuning1. Both cell types are th...

    Lauren Chessum, Maggie S. Matern, Michael C. Kelly, Stuart L. Johnson, Yoko Ogawa in Nature (2018)

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    Open Access

    Gfi1Cre mice have early onset progressive hearing loss and induce recombination in numerous inner ear non-hair cells

    Studies of developmental and functional biology largely rely on conditional expression of genes in a cell type-specific manner. Therefore, the importance of specificity and lack of inherent phenotypes for Cre-dri...

    Maggie Matern, Sarath Vijayakumar, Zachary Margulies, Beatrice Milon in Scientific Reports (2017)

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    Open Access

    RFX transcription factors are essential for hearing in mice

    Sensorineural hearing loss is a common and currently irreversible disorder, because mammalian hair cells (HCs) do not regenerate and current stem cell and gene delivery protocols result only in immature HC-lik...

    Ran Elkon, Beatrice Milon, Laura Morrison, Manan Shah in Nature Communications (2015)