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Article
Helios is a key transcriptional regulator of outer hair cell maturation
The sensory cells that are responsible for hearing include the cochlear inner hair cells (IHCs) and outer hair cells (OHCs), with the OHCs being necessary for sound sensitivity and tuning1. Both cell types are th...
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Article
Open AccessGfi1Cre mice have early onset progressive hearing loss and induce recombination in numerous inner ear non-hair cells
Studies of developmental and functional biology largely rely on conditional expression of genes in a cell type-specific manner. Therefore, the importance of specificity and lack of inherent phenotypes for Cre-dri...
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Article
Open AccessRFX transcription factors are essential for hearing in mice
Sensorineural hearing loss is a common and currently irreversible disorder, because mammalian hair cells (HCs) do not regenerate and current stem cell and gene delivery protocols result only in immature HC-lik...