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Article
Open AccessExtending fluorescence anisotropy to large complexes using reversibly switchable proteins
The formation of macromolecular complexes can be measured by detection of changes in rotational mobility using time-resolved fluorescence anisotropy. However, this method is limited to relatively small molecul...
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Article
Open AccessAnti-SARS-CoV-2 antibody-containing plasma improves outcome in patients with hematologic or solid cancer and severe COVID-19: a randomized clinical trial
Patients with cancer are at high risk of severe coronavirus disease 2019 (COVID-19), with high morbidity and mortality. Furthermore, impaired humoral response renders severe acute respiratory syndrome coronavi...
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Article
Open AccessSmall and long RNA transcriptome of whole human cerebrospinal fluid and serum as compared to their extracellular vesicle fractions reveal profound differences in expression patterns and impacts on biological processes
Next generation sequencing (NGS) of human specimen is expected to improve prognosis and diagnosis of human diseases, but its sensitivity urges for well-defined sampling and standardized protocols in order to a...
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Article
Listen and Read: The Battle for Attention: A New Report About Key Audience Behaviour in the Age of eBooks, Audiobooks and Podcasts
The media landscape, including book publishing, is undergoing rapid development and profound change due to the digitization of content, and its respective sales and marketing channels. It is now possible to co...
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Article
Open AccessRobust and durable serological response following pediatric SARS-CoV-2 infection
The quality and persistence of children’s humoral immune response following SARS-CoV-2 infection remains largely unknown but will be crucial to guide pediatric SARS-CoV-2 vaccination programs. Here, we examine...
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Article
Open AccessA Randomized Open label Phase-II Clinical Trial with or without Infusion of Plasma from Subjects after Convalescence of SARS-CoV-2 Infection in High-Risk Patients with Confirmed Severe SARS-CoV-2 Disease (RECOVER): A structured summary of a study protocol for a randomised controlled trial
Primary objectives
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Article
Open AccessNephronophthisis gene products display RNA-binding properties and are recruited to stress granules
Mutations of cilia-associated molecules cause multiple developmental defects that are collectively termed ciliopathies. However, several ciliary proteins, involved in gating access to the cilium, also assume l...
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Article
Open AccessMultiple-party funding: tensions and related consequences for academic research in Europe
European universities are experiencing increasing financial pressures. Given that governmental budgets are cut, they have to additionally rely on further sources of funding. Multi-party funding, however, is no...
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Reference Work Entry In depth
Ambidexterity
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Chapter
Game of Thrones – ein gnostisches Heldenepos aus dem „finsteren“ Mittelalter
Keine andere HBO-Serie erzielte bislang höhere Einschaltquoten als Game of Thrones. Die im Sommer 2017 erschienene, siebte und damit vorletzte Staffel erreichte nach Angaben der HBO allein in den USA über 10 Mio....
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Article
Synthetic microbiota reveal priority effects and keystone strains in the Arabidopsis phyllosphere
Multicellular organisms, including plants, are colonized by microorganisms, some of which are beneficial to growth and health. The assembly rules for establishing plant microbiota are not well understood, and ...
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Article
Open AccessExperimental and computational analyses reveal that environmental restrictions shape HIV-1 spread in 3D cultures
Pathogens face varying microenvironments in vivo, but suitable experimental systems and analysis tools to dissect how three-dimensional (3D) tissue environments impact pathogen spread are lacking. Here we deve...
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Article
Metabolic perturbations caused by depletion of nephronophthisis factor Anks6 in mIMCD3 cells
Nephronophthisis (NPH) is an inherited form of cystic kidney disease with various extrarenal manifestations accounting for the largest amount of endstage renal disease in childhood. Patient mutations of Anks6 ...
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Chapter
Was suchen Führungskräfte im Kloster?
Man stößt ab und an auf Berichte, dass Führungskräfte aus der Wirtschaft ihren Urlaub oder eine Auszeit im Kloster verbringen. Jüngst kursierten z.B. Berichte über einen Aufenthalt von Bodo Janssen, Inhaber de...
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Article
Open AccessMetabolic Phenoty** of Anks3 Depletion in mIMCD-3 cells - a Putative Nephronophthisis Candidate
Nephronophthisis (NPH) is an autosomal recessive form of cystic kidney disease and the leading cause of hereditary kidney failure in children and young adults. Like other NPH proteins, the NPHP16/Anks6-interac...
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Reference Work Entry In depth
HIV-1 Maturation
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Chapter and Conference Paper
Deep Particle Tracker: Automatic Tracking of Particles in Fluorescence Microscopy Images Using Deep Learning
Tracking of particles in fluorescence microscopy image sequences is essential for studying the dynamics of subcellular structures and virus structures. We introduce a novel particle tracking approach using an ...
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Living Reference Work Entry In depth
Ambidexterity
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Article
Open AccessSheep in Wolf’s Clothing: The Role of Artifacts in Interpretive Schema Change
In this paper, we investigate the role of artifacts in a failed project that aimed at implementing a new culture of dealing with errors in a hospital by transferring safety standards from the aviation industry...
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Article
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