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  1. Article

    Open Access

    A high-throughput metabolomics in vitro platform for the characterization of hepatotoxicity

    Cell-based metabolomics provides multiparametric physiologically relevant readouts that can be highly advantageous for improved, biologically based decision making in early stages of compound development. Here...

    Sabina Ramirez-Hincapie, Barbara Birk, Philipp Ternes… in Cell Biology and Toxicology (2023)

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  2. No Access

    Article

    3D-Hunde-Lebersphäroide für die präklinische in vitro-Testung

    Generation of dog 3D spheroids has been hampered by the fact that dog hepatocytes do not always form spheroids in standard 96-well low attachment plates making in vitro hepatotoxicity testing in high-throughput-f...

    Annamarija Raic, Carina Oberfrank, Barbara Birk, Reiner Class… in BIOspektrum (2021)

  3. No Access

    Article

    Kofaktor-Mikroarrays zur Identifikation von Kernrezeptorliganden

    Different in vitro approaches exist to identify agonistic or antagonistic activity of chemical substances concerning nuclear receptors, since adverse effects in vivo can be the consequence. The recruitment of cor...

    Philipp Demuth, Barbara Birk, Nadine Roth, Robert Landsiedel… in BIOspektrum (2019)

  4. No Access

    Article

    Thrombin causes the Enrichment of Rat Brain Primary Cultures with Ependymal Cells Via Protease-Activated Receptor 1

    Ependymal cell culture models from rat have been developed over the last 20 years to facilitate biochemical studies on this least-studied glial cell type. The cell culture protocol calls for the presence of th...

    Felix Tritschler, Radovan Murín, Barbara Birk, Jürgen Berger… in Neurochemical Research (2007)