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Article
Tumor-responsive dynamic nanoassemblies for boosted photoimmunotherapy
Photoimmunotherapy (PIT) is an emerging therapeutic approach that integrates phototherapy and immunotherapy to eliminate primary tumors under an appropriate dosage of local light irradiation, while simultaneou...
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Article
Open AccessEffects of the surface charge of polyamidoamine dendrimers on cellular exocytosis and the exocytosis mechanism in multidrug-resistant breast cancer cells
Polyamidoamine (PAMAM) dendrimer applications have extended from tumor cells to multidrug-resistant tumor cells. However, their transportation in multidrug-resistant tumor cells remains unclear. Herein, we inv...
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Article
Open AccessPeptide-Mediated Tumor Targeting by a Degradable Nano Gene Delivery Vector Based on Pluronic-Modified Polyethylenimine
Polyethylenimine (PEI) is considered to be a promising non-viral gene delivery vector. To solve the toxicity versus efficacy and tumor-targeting challenges of PEI used as gene delivery vector, we constructed a...
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Article
Protective Effect of Ginkgolide B Against Acute Spinal Cord Injury in Rats and Its Correlation with the JAK/STAT Signaling Pathway
This study aimed to investigate the correlation between ginkgolide B (GB) and the JAK/STAT signaling pathway and to explore its regulating effect on secondary cell apoptosis following spinal cord injury (SCI),...
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Article
Surface modification with pluronic P123 enhances transfection efficiency of PAMAM dendrimer
To improve gene delivery efficiency and decrease cytotoxicity of polyamidoamine (PAMAM) polymers, P123-g-PAMAM was synthesized by modifying PAMAM with pluronic P123. The structure of the synthesized polymers was ...
