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Article
Crosstalk between endothelial progenitor cells and HCC through periostin/CCL2/CD36 supports formation of the pro-metastatic microenvironment in HCC
Metastasis causes most cancer-related deaths, and the role and mechanism of periostin (POSTN) in the metastasis of hepatocellular carcinoma (HCC) remain undiscovered. In this study, DEN and HTVi HCC models wer...
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Article
Open AccessAZGP1 activation by lenvatinib suppresses intrahepatic cholangiocarcinoma epithelial-mesenchymal transition through the TGF-β1/Smad3 pathway
Intrahepatic cholangiocarcinoma (ICC) is a primary liver malignancy and is characterized by highly aggressive and malignant biological behavior. Currently, effective treatment strategies are limited. The effec...
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Article
Open AccessCAFs-derived SCUBE1 promotes malignancy and stemness through the Shh/Gli1 pathway in hepatocellular carcinoma
The tumour microenvironment and cirrhotic liver are excellent sources of cancer-associated fibroblasts (CAFs), which participate in carcinogenesis. Thus, it is important to clarify the crosstalk between CAFs a...
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Article
Open AccessLncRNA HEPFAL accelerates ferroptosis in hepatocellular carcinoma by regulating SLC7A11 ubiquitination
Ferroptosis is a new type of cell death that has been recognized in recent years and is different from apoptosis, autophagy, and necrosis. It is mainly due to cellular iron homeostasis and lipid peroxidation o...
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Article
Paraquat Inhibits Autophagy Via Intensifying the Interaction Between HMGB1 and α-Synuclein
Paraquat, a widely used herbicide, is associated with an increased risk of Parkinson’s disease (PD). PQ induces upregulation and accumulation of α-synuclein in neurons, which is one of the major pathological h...
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Article
Taurine protects dopaminergic neurons in paraquat-induced Parkinson’s disease mouse model through PI3K/Akt signaling pathways
Taurine (Tau) is one of the most abundant amino acids in the brain and regulates physiological functions in the central nervous system, including anti-inflammatory effects. There is growing evidence that micro...
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Article
Open AccessSitagliptin activates the p62–Keap1–Nrf2 signalling pathway to alleviate oxidative stress and excessive autophagy in severe acute pancreatitis-related acute lung injury
Acute lung injury (ALI) is a complication of severe acute pancreatitis (SAP). Sitagliptin (SIT) is a DPP4 inhibitor that exerts anti-inflammatory and antioxidant effects; however, its mechanism of action in SA...
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Article
Photonic frequency-multiplication millimeter-wave generation with cascaded DPMZMs
A novel structure for photonic frequency-multiplication millimeter-wave (mm-wave) generation with two cascaded dual-parallel Mach–Zehnder modulators (DPMZMs) but no optical filter is demonstrated. By properly ...
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Article
Adoptive cell therapy of patient-derived renal cell carcinoma xenograft model with IL-15-induced γδT cells
Adoptive transfer of γδ T cells is an attractive approach for cell-based immunotherapy in treatment of renal cell carcinoma (RCC). Interleukin-15 (IL-15) is the key physiological cytokine that regulates γδ T c...
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Article
Online evolution reconstruction from a single measurement record with random time intervals for quantum communication
Online reconstruction of a time-variant quantum state from the encoding/decoding results of quantum communication is addressed by develo** a method of evolution reconstruction from a single measurement recor...
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Article
Open AccessOverexpression of CIP2A is associated with poor prognosis in multiple myeloma
Cancerous inhibitor of protein phosphatase 2A (CIP2A), an endogenous protein phosphatase 2A (PP2A) inhibitor, has been identified as an oncoprotein in promoting cancer initiation and progression of several typ...
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Article
Representing expectation values of projectors as series for evolution reconstruction
We propose a Hamiltonian-independent approach for evolution reconstruction, which reconstructs the density operator of an evolving quantum system on the basis of recovering its time-varying expectation values ...
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Article
Efficient theoretical model and numerical simulation for optimization of gain-switched thulium-doped fiber lasers
We demonstrate an effective and simplified theoretical model of the in-band-pumped gain-switched thulium-doped fiber laser in which the effective pump power and effective population density are defined as the ...
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Article
Immunoreceptor TIGIT inhibits the cytotoxicity of human cytokine-induced killer cells by interacting with CD155
T cell Ig and ITIM domain (TIGIT) is a newly identified inhibitory receptor expressed on T and natural killer (NK) cells. Cytokine-induced killer (CIK) cells express CD3 and CD56 molecules, and share functiona...
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Chapter and Conference Paper
A Quick Method of Measuring the Transmission Time of Optical Fiber
It is difficult to determine the peak of optical signal transmission time in the time transfer system based on single photon detector. In order to solve the problem, a novel scanning measurement method is prop...
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Article
Oncolytic adenovirus armed with shRNA targeting MYCN gene inhibits neuroblastoma cell proliferation and in vivo xenograft tumor growth
MYCN amplification and p53 inactivation are two typical characteristics of aggressive neuroblastomas and are strongly associated with cancer progression and treatment failure. In an effort to develop new thera...
