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  1. Article

    Open Access

    Rapid acceleration of KRAS-mutant pancreatic carcinogenesis via remodeling of tumor immune microenvironment by PPARδ

    Pancreatic intraepithelial neoplasia (PanIN) is a precursor of pancreatic ductal adenocarcinoma (PDAC), which commonly occurs in the general populations with aging. Although most PanIN lesions (PanINs) harbor ...

    Yi Liu, Yasunori Deguchi, Daoyan Wei, Fuyao Liu in Nature Communications (2022)

  2. Article

    Open Access

    Ductal activation of oncogenic KRAS alone induces sarcomatoid phenotype

    Salivary duct carcinoma (SDC) is an uncommon, but aggressive malignant tumor with a high mortality rate. Herein, we reported the detection of somatic KRAS A146T and Q61H mutations in 2 out of 4 (50%) sarcomatoid ...

    Yong Fu, Zobeida Cruz-Monserrate, H. Helen Lin, Yiyin Chung, Baoan Ji in Scientific Reports (2015)