956 Result(s)
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Article
Open AccessLINC01133 promotes pancreatic ductal adenocarcinoma epithelial–mesenchymal transition mediated by SPP1 through binding to Arp3
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with limited treatment methods. Long non-coding RNAs (lncRNAs) have been found involved in tumorigenic and progression. The present study revealed th...
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Open AccessSimultaneous de novo calling and phasing of genetic variants at chromosome-scale using NanoStrand-seq
The successful accomplishment of the first telomere-to-telomere human genome assembly, T2T-CHM13, marked a milestone in achieving completeness of the human reference genome. The upcoming era of genome study wi...
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Open Accessquantms: a cloud-based pipeline for quantitative proteomics enables the reanalysis of public proteomics data
The volume of public proteomics data is rapidly increasing, causing a computational challenge for large-scale reanalysis. Here, we introduce quantms (https://quant,ms.org/
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Erratum to: Cholesterol homeostasis regulated by ABCA1 is critical for retinal ganglion cell survival
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Pan-drug resistance and hypervirulence in a human fungal pathogen are enabled by mutagenesis induced by mammalian body temperature
The continuing emergence of invasive fungal pathogens poses an increasing threat to public health. Here, through the China Hospital Invasive Fungal Surveillance Net programme, we identified two independent cas...
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Exogenous melatonin enhanced cadmium stress tolerance of cucumber seedlings (Cucumis sativus L.)
Cadmium (Cd) stress seriously affects cucumber growth, yield, and quality. Melatonin (MT) can enhance plant resistance to abiotic stresses. However, studies on the mechanism of MT in enhancing plant resistance...
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Open AccessPromotion of stem cell-like phenotype of lung adenocarcinoma by FAM83A via stabilization of ErbB2
Lung cancer stands as the leading cause of mortality among all types of tumors, with over 40% of cases being lung adenocarcinoma (LUAD). Family with sequence similarity 83 member A (FAM83A) emerges as a notabl...
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Permafrost carbon cycle and its dynamics on the Tibetan Plateau
Our knowledge on permafrost carbon (C) cycle is crucial for understanding its feedback to climate warming and develo** nature-based solutions for mitigating climate change. To understand the characteristics ...
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Open AccessEphA2 promotes the transcription of KLF4 to facilitate stemness in oral squamous cell carcinoma
Ephrin receptor A2 (EphA2), a member of the Ephrin receptor family, is closely related to the progression of oral squamous cell carcinoma (OSCC). Cancer stem cells (CSCs) play essential roles in OSCC developme...
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In vivo AAV–SB-CRISPR screens of tumor-infiltrating primary NK cells identify genetic checkpoints of CAR-NK therapy
Natural killer (NK) cells have clinical potential against cancer; however, multiple limitations hinder the success of NK cell therapy. Here, we performed unbiased functional map** of tumor-infiltrating NK (T...
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The m6A methyltransferase METTL3 drives neuroinflammation and neurotoxicity through stabilizing BATF mRNA in microglia
Persistent neuroinflammation and progressive neuronal loss are defining features of acute brain injury including traumatic brain injury (TBI) and cerebral stroke. Microglia, the most abundant type of brain-res...
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Pharmacological Activities of Green Synthesized Silver Nanoparticles and Leaf, Root Extracts of Muntingia calabura
Muntingia calabura (MC) is a valuable medicinal plant with many bioactive compounds that can be used to treat inflammation, ulcers and headaches. The current study aimed to evaluate the antioxidant, anti-inflamma...
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Open AccessEvolutionary radiation strategy revealed in the Scarabaeidae with evidence of continuous spatiotemporal morphology and phylogenesis
Evolutionary biology faces the important challenge of determining how to interpret the relationship between selection pressures and evolutionary radiation. The lack of morphological evidence on cross-species r...
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Open AccessPhosphorylated FOXQ1, a novel substrate of JNK1, inhibits sorafenib-induced ferroptosis by activating ETHE1 in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a highly heterogeneous and malignant cancer with poor overall survival. The application of sorafenib is a major breakthrough in the treatment of HCC. In our study, FOXQ1 was s...
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Open AccessFBP1 orchestrates keratinocyte proliferation/differentiation and suppresses psoriasis through metabolic control of histone acetylation
Keratinocyte proliferation and differentiation in epidermis are well-controlled and essential for reacting to stimuli such as ultraviolet light. Imbalance between proliferation and differentiation is a charact...
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Open AccessMutations in wheat TaAPA2 gene result in pleiotropic effects on plant architecture
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APOE3ch alleviates Aβ and tau pathology and neurodegeneration in the human APPNL-G-F cerebral organoid model of Alzheimer’s disease
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Author Correction: Re-engineering the adenine deaminase TadA-8e for efficient and specific CRISPR-based cytosine base editing
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Promoter Mutation of the bZIP Transcription Factor BdABF Accelerates Flowering in Brachypodium distachyon
Flowering time plays an important role in crop regional adaptation, yield and reproductive success. ABRE BINDING FACTORs (ABFs) are bZIP transcription factors that participate in various plant biological proce...
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Open AccessOTUD5 promotes the inflammatory immune response by enhancing MyD88 oligomerization and Myddosome formation
Myddosome is an oligomeric complex required for the transmission of inflammatory signals from TLR/IL1Rs and consists of MyD88 and IRAK family kinases. However, the molecular basis for the self-assemble of Mydd...
