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Article
Glial cell line-derived neurotrophic factor protects against ischemia/hypoxia-induced brain injury in neonatal rat
Ischemic/hypoxic brain damage induced in 7-day-old rats was significantly attenuated in a dose-dependent manner by intracerebral injection of glial cell line-derived neurotrophic factor (GDNF; 2 or 4 μg) with...
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Article
Repair and reconstruction of the cortical plate following closed cryogenic injury to the neonatal rat cerebrum
A cryogenic lesion was induced in the parietal cortex of neonatal rats at postnatal day 2, and the chronological sequence of cellular events during repair and reconstruction of the cortical plate examined. Ser...
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Article
Effects of methylmercury on neuroepithelial germinal cells in the develo** telencephalic vesicles of mice
Methylmercury (MeHg) poisoning (20 mg/kg body weight) in embryonic mice resulted in significant reductions of mitotic indices in the neuroepithelial germinal cells of the telencephalon at the ventricular surfa...
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Article
The behavior of the extracellular matrix and the basal lamina during the repair of cryogenic injury in the adult rat cerebral cortex
A well-defined coagulative lesion was produced in the fronto-parietal cortex of adult rats by application of a cold probe, and the chronological sequence of events during the healing process, particularly the ...
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Article
Developmental events during the early stages of cerebral cortical neurogenesis in man
The telencephalic vesicles of early human embryos and fetuses ranging from 6–18 weeks of ovulation age were subjected to correlative light and electron microscopic, immunocytochemical and Golgi analysis. The c...
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Article
Hydrocephalus following prenatal methylmercury poisoning
Prenatal methylmercury poisoning of C57BL/6J mice was followed by the development of communicating hydrocephalus in 15% to 25% of surviving offspring. Although examination of the serially sectioned cerebral aq...
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Article
Abnormal neuronal distribution within the cerebral cortex after prenatal methylmercury intoxication
C57BL/6J mice were poisoned with methylmercury during pregnancy, and the location of heavily labeled neurons generated at embryonic day 16 was determined by tritiated thymidine autoradiography of the cerebral ...
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Article
Cortical dysplasia associated with massive ectopia of neurons and glial cells within the subarachnoid space
A detailed neuropathological study of the brain of a 31-day-old premature newborn infant revealed the presence of massive ectopia of neurons and glial cells within the subarachnoid space. The extrusion of neur...
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Article
Disturbances in neuronal migration and laminar cortical organization associated with multicystic encephalopathy in the Pena-Shokeir syndrome
The Pena-Shokeir syndrome is characterized by intrauterine growth retardation, camptodactyly, multiple ankyloses, facial anomalies and pulmonary hypoplasia. The condition is thought to be inherited in an autos...
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Article
Abnormal neuronal migration and gliomatosis cerebri in epidermal nevus syndrome
A detailed neuropathologic examination of the brain of a child with the typical epidermal nevus syndrome revealed a primary disturbance of development of the brain. The developmental disturbance consisted of a...
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Article
Occult malignant astrocytoma of pons with extracranial metastasis to bone prior to craniotomy
A 23-year-old man presented with signs of increased intracranial pressure. CAT scan, cisternogram, and angiogram on admission were reported to be normal. Lumbar puncture revealed elevated pressure and protein ...
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Article
A Golgi and electron-microscopic study of cerebellum in methylmercury-poisoned neonatal mice
Neonatal C57BL/6J mice were injected with 5 mg/kg body weight of203Hg-labeled methylmercuric chloride on postnatal days 3, 4, and 5, totaling 15 mg/kg body weight per animal. The experimental and control animals ...