Chirurgisches Forum und DGAV Forum 2009
für experimentelle und klinische Forschung 126. Kongress der Deutschen Gesellschaft für Chirurgie München, 28.04.-01.05.2009
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Article
Paclitaxel-coated stents to prevent hyperplastic proliferation of ureteral tissue: from in vitro to in vivo
Ureteric stents have become an indispensable tool in the armamentarium of every urologist. However, they carry their own morbidity resulting mostly from infectious or abacterial fouling and biofilm formation, ...
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Article
Open AccessPDGF-BB regulates splitting angiogenesis in skeletal muscle by limiting VEGF-induced endothelial proliferation
VEGF induces normal or aberrant angiogenesis depending on its dose in the microenvironment around each producing cell in vivo. This transition depends on the balance between VEGF-induced endothelial stimulatio...
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Article
Open AccessDecitabine demonstrates antileukemic activity in B cell precursor acute lymphoblastic leukemia with MLL rearrangements
Promotor hypermethylation of CpG islands is common in B cell precursor acute lymphoblastic leukemia (BCP-ALL) with mixed lineage leukemia (MLL) gene rearrangements. Hypomethylating agents (HMA) such as azaciti...
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Article
Diabetes aggravates acute pancreatitis and inhibits pancreas regeneration in mice
It is well established that acute pancreatitis often causes diabetes and that a high blood glucose level associated with pancreatitis is a marker of poor prognosis. The aim of this study was to evaluate if dia...
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Article
„Small-for-size“
Die Besonderheit der hepatischen Makrozirkulation, d. h. die parallele portalvenöse und arterielle Blutversorgung, ist von erheblicher Relevanz für die Leberchirurgie. Nach ausgedehnter Hepatektomie oder Trans...
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Article
Effects on the ubiquitin proteasome system after closed soft-tissue trauma in rat skeletal muscle
Previous studies have suggested that an increased catabolic stage of skeletal muscle in pathological situations is mainly a reflection of ubiquitin–proteasome system-controlled proteolysis. The proteolytic mec...
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Chapter and Conference Paper
ATIII und NAC hemmen die mikrovaskuläre Thrombusbildung im postischämischen Gewebe in vivo
Combined pancreas-kidney transplantation is one therapeutic option of Diabetes mellitus. In the early postoperative period pancreatic venous thrombosis is one of the major complications leading to allograft dy...
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Chapter and Conference Paper
Eine Mutation innerhalb der ATP8-Synthase verbessert den hepatischen Energiestatus im murinen Modell des akuten septischen Leberversagens
The (dys)function of mitochondria plays an important role in the development of multiple organ failure. Therefore, the implications of mitochondrial (dys)function in the development of multiple organ failure a...
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Chapter and Conference Paper
Darbepoetin-α verringert die Nekroinflammation und mildert die cholestatische Fibrose in Mäusen
Biliary obstruction and cholestasis result in hepatocellular necro-inflammation and lead to the development of liver fibrosis. Herein, we evaluated the therapeutic efficacy of Darbepoetin-α (DPO), a recombinan...
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Article
Zehn Jahre „Praktischer Kurs für Viszeralchirurgie Warnemünde“
Das Angebot mehrtägiger praktischer Kurse für Chirurgie bietet die kosten- und personalintensive Chance, durch den Einsatz eines engen Lehrer-Schüler-Kontaktes einer großen Gruppe von Chirurgen, einen kliniküb...
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Book and Conference Proceedings
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Chapter and Conference Paper
Simvastatin reduces ischemia-induced inflammation and stimulates neovascularisation of critically perfused flaps
Background: Critical perfusion conditions may impair the function of surgical flaps resulting in partial or even total necrosis. Statins have shown to exert protection in myocardial ischemia thro...
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Chapter and Conference Paper
Prednisolon reduces the ATG-dependent microvascular thrombus formation in postischemic tissue in vivo
Single-shot ATG as induction followed by Tacrolimus, MMF and Prednisolon is a well established immunosuppressive regimen used in clinical organ transplantation. In the early postoperative period pancreatic ven...
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Article
Arginine reduces leukocyte/endothelial cell interaction in a model of normotensive endotoxemia without attenuating capillary perfusion failure
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Chapter and Conference Paper
In vivo Analyse der Biokompatibilität und Gewebeintegration des synthetischen Knochenersatzstoffes NanoBone®
One of the major challenges in tissue engineering of bone substitutes are adequate vascularization and biocompatibility of the implant. Thus, the temporal course of neovascularization and the microvascular inf...
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Chapter and Conference Paper
Langzeituntersuchungen zur Regeneration von traumatisiertem Gewebe nach komplexer Nerven-Muskelverletzung an der Ratte
The therapy of combined peripheral nerve-muscle injuries is of high clinical relevance in trauma surgery. Nerve injuries lead to atrophy of the innervated uninjured muscle. Until now there are no studies addre...
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Chapter and Conference Paper
Erythropoietin verzögert die dermale Re-Epithelialisierung und inhibiert die Gefäßreifung in einem neuen in vivo Modell der Hautwundheilung
In skin wound healing apoptosis is an essential prerequisite. Erythropoietin (EPO) is reported to improve skin wound healing and to stimulate angiogenesis, however, exerts anti-apoptotic properties which could...
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Chapter and Conference Paper
Melatonin beeinträchtigt die Mikrozirkulation und verstärkt die Nekrose kritisch perfundierten Gewebes in »random pattern flaps«
Background: Melatonin is predominantly produced in the pineal gland, the retina and the enterochromaphine cells during the dark period. As receptors for melatonin are spread in diverse tissues, m...
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Chapter and Conference Paper
Stickstoffmonoxid vermindert den Organschaden und unterstützt die Regeneration in »reduced-size«-Lebern durch eine verbesserte hepatoarterielle Versorgung
The »small-for-size«-syndrome after reduced-size liver transplantation or extended hepatectomy is characterized by severe liver dysfunction or liver failure. Beside portal hyperperfusion with high intravascula...
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Chapter and Conference Paper
Rolle des mitochondrialen «Uncoupling Protein 2» in der Vermittlung des apoptotischen und nekrotischen Zelltods beim akuten septischen Leberversagen
Liver cell injury and cell death are prominent features in the pathogenesis of acute liver failure. Mitochondrial Uncoupling Protein 2 (UCP2) plays a controversial role in liver cell death through its involvem...
