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  1. Article

    Open Access

    Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA

    Avapritinib is the only potent and selective inhibitor approved for the treatment of D842V-mutant gastrointestinal stromal tumors (GIST), the most common primary mutation of the platelet-derived growth factor ...

    A. Teuber, T. Schulz, B. S. Fletcher, R. Gontla, T. Mühlenberg… in Nature Communications (2024)

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  2. No Access

    Article

    Indoleamine 2,3-dioxygenase attenuates inhibitor development in gene-therapy-treated hemophilia A mice

    A serious impediment to gene and protein replacement therapy in hemophilia A is the development of inhibitors. Mechanisms responsible for inhibitor development include T-cell-dependent adaptive immune response...

    L Liu, H Liu, C Mah, B S Fletcher in Gene Therapy (2009)

  3. No Access

    Article

    Feeding behavior ofRhagoletis pomonella flies (Diptera: Tephritidae): Effect of initial food quantity and quality on food foraging, handling costs, and bubbling

    Under seminatural conditions feeding and postfeeding behaviors of individual apple maggot flies, Rhagoletis pomonella(Diptera: Tephritidae), were recorded after flies were presented with yeast hydrolysate or suc...

    J. Hendrichs, B. S. Fletcher, R. J. Prokopy in Journal of Insect Behavior (1993)

  4. No Access

    Article

    Identification of the major components in the secretion from the rectal pheromone glands of the queensland fruit fliesDacus tryoni andDacus neohumeralis (Diptera: Tephritidae)

    The secretion from the rectal pheromone glands of maleDacus tryoni andDacus neohumeralis is largely a mixture of six aliphatic amides. In order of decreasing quantity these areN-3-methylbutylpropanamide,N-3-methy...

    T. E. Bellas, B. S. Fletcher in Journal of Chemical Ecology (1979)

  5. No Access

    Article

    The release ofOpius concolor andO. Concolor var.Siculus [Hym.: Braconidae] against the spring generation ofDacus oleae [Dipt.: Trypetidae] on Corfu

    Releases ofOpius concolor Szepl. andO. concolor var.siculus Mon. were carried out in the spring to determine if they could be used as a biological control agent against the heavy infestation ofDacus oleae Gmel. w...

    E. Kapatos, B. S. Fletcher, S. Pappas, Y. Laudeho in Entomophaga (1977)

  6. No Access

    Article

    Storage and Release of a Sex Pheromone by the Queensland Fruit Fly, Dacus tryoni (Diptera: Trypetidae)

    Dacus tryoni (Frogg.) mates at dusk. During courtship, males stridulate by drawing their wings across a pair of combs formed from large bristles on the third abdominal tergite. This produces a high pitched buzz, ...

    B. S. FLETCHER in Nature (1968)