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Chapter
New Pharmacological Perspectives on Nootropic Drugs
Nootropic drugs literally mean drugs that act on the mind. The term nootropic derives from the Greek words noos (mind) and tropein (toward), and was coined in about 1972 by Corneliu Giurgea to categorize the new ...
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Article
Arousal deficit shown in aged rat's quantitative EEG and ameliorative action of pramiracetam compared to piracetam
The basal EEG profile of the aged Fisher-344 rat was consistently different from that of the young rat, showing dominant high voltage slow-wave components. These slow waves were present in both the frontal cer...
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Article
Pharmacologic therapeutic window of pramiracetam demonstrated in behavior, EEG, and single neuron firing rates
Following oral or intravenous administration, a representative cognition activator drug, pramiracetam sulfate, is shown to have a pharmacologic therapeutic window at three different levels of study: learned be...
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Article
Pyrazapon (CI-683): A new antianxiety agent
Pyrazapon, a pyrazolodiazepinone, exerts strong disinhibitory effects on behavior in a variety of animal tests (ingestion of a novel food substance, conditioned conflict, hypothalamic self-stimulation). In tes...
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Article
A simple and specific screen for benzodiazepine-like drugs
Naive, non-hungry, non-thirsty rats ingested inordinate amounts of a sweetened milk solution when given their first opportunity to drink the solution while under the influence of benzodiazepine drugs. Among ma...
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Article
Appetitive thresholds of the hypothalamic “feeding area” self-determined in the rat
Increasing intensities of electrical stimulation were delivered to the “feeding area” of the lateral hypothalamus of unrestrained rats. The animals could lick a tube to obtain milk or water. Licking the tube a...
