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Article
Nef: out and in?
Lentiviral Nef protein has many functions in the evasion of host immune defenses. Another 'chink' in the host immune 'armor' has now been exposed by Nef's ability to inhibit immunoglobulin class switching.
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Article
Hide, shield and strike back: how HIV-infected cells avoid immune eradication
HIV escapes the immune system by hiding inside cells. In resting cells, blocks to the initiation and elongation of viral transcription have been proposed.
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Article
Mutation in a winged-helix DNA-binding motif causes atypical bare lymphocyte syndrome
Bare lymphocyte syndrome (BLS) is an autosomal recessive severe-combined immunodeficiency that can result from mutations in four different transcription factors that regulate the expression of major histocompa...
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Article
Role of the X2 box in activated transcription from the DRA promoter in B cells
We investigated the function of the evolutionary conserved X2 box in the promoter of the HLA-DRA gene from the human major histocompatibility complex (MHC) in resting and activated B cells. NF-X2, which contains...
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Article
The function of the octamer-binding site in the DRA promoter
The octamer binding site, which is located immediately upstream of the poorly conserved DRA TATA sequence, is important fof high levels of expression of this human major histocompatibility class II gene in B cell...
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Article
Transcriptional regulation of HLA class-II genes
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Article
Methylation patterns of HLA-DR alpha genes in six mononuclear cell lines
The relationship between DNA methylation and HLA-DR α gene expression was investigated in six mononuclear cell lines. RPMI-4265 (B cell) and HUT-78 (T cell) constitutively express HLA-DR. HL-60 (myelomonocyte) an...