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Article
SIRT1 mediates breast cancer development and tumorigenesis controlled by estrogen-related receptor β
Silent mating type information regulation 2 homolog 1 (SIRT1) is a class III histone deacetylase (HDAC) that is NAD + dependent and essential for metabolism, senescence, and cell survival. SIRT1 is overexpress...
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Article
Open AccessStromal cartilage oligomeric matrix protein as a tumorigenic driver in ovarian cancer via Notch3 signaling and epithelial-to-mesenchymal transition
Cartilage oligomeric matrix protein (COMP), an extracellular matrix glycoprotein, is vital in preserving cartilage integrity. Further, its overexpression is associated with the aggressiveness of several types ...
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Article
Open AccessEstrogen receptor α dependent regulation of estrogen related receptor β and its role in cell cycle in breast cancer
Breast cancer (BC) is highly heterogeneous with ~ 60–70% of estrogen receptor positive BC patient’s response to anti-hormone therapy. Estrogen receptors (ERs) play an important role in breast cancer progressio...
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Article
Open AccessHer2 Ile655Val polymorphism and its association with breast cancer risk: an updated meta-analysis of case-control studies
Breast cancer (BC) is one of the most common types of cancer in women worldwide. Several factors including genetic and environmental have been linked with susceptibility to development of BC. Her2 is a transmembr...
