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  1. No Access

    Article

    Muscarinic agonists reduce tau phosphorylation in non-neuronal cells via GSK-3β inhibition and in neurons

    Muscarinic agonists alter the metabolism of amyloid precursor protein, leading to an increase in α-secretase cleavage and a decreased production of amyloidogenic peptides; suggesting that these compounds migh...

    O. V. Forlenza, J. M. Spink, R. Dayanandan… in Journal of Neural Transmission (2000)

  2. No Access

    Article

    Cytoskeletal pathology in familial cerebral amyloid angiopathy (British type) with non-neuritic amyloid plaque formation

    The histological features of familial cerebral amyloid angiopathy (British type) with non-neuritic amyloid plaque formation (FAB) include deposition of amyloid, (supposedly associated with the C-terminal frag...

    T. Revesz, J. L. Holton, B. Doshi, B. H. Anderton, F. Scaravilli… in Acta Neuropathologica (1999)

  3. No Access

    Article

    Relationships between Lewy bodies and pale bodies in Parkinson's disease

    The prevalance of pale bodies and Lewy bodies was studied in the substantia nigra of 12 patients with typical Parkinson's disease (PD), in 5 patients with diffuse Lewy body disease (DLBD), and in a group of ne...

    G. E. Dale, A. Probst, P. Luthert, J. Martin, B. H. Anderton… in Acta Neuropathologica (1992)

  4. No Access

    Article

    New aspects of the pathology of neurodegenerative disorders as revealed by ubiquitin antibodies

    Ubiquitin has previously been identified as a component of neuronal inclusions in neurodegenerative disorders. In this investigation, we examined tissue from cases of Alzheimer's disease (AD), Pick's discase, ...

    P. N. Leigh, A. Probst, G. E. Dale, D. P. Power, J. -P. Brion… in Acta Neuropathologica (1989)

  5. No Access

    Article

    Senile plaque neurites fail to demonstrate anti-paired helical filament and anti-microtubule-associated protein-tau immunoreactive proteins in the absence of neurofibrillary tangles in the neocortex

    Although much work has been directed recently towards unravelling the protein chemistry of neurofibrillary tangle (NFT) and senile plaque (SP) components in Alzheimer's disease, the pathogeneses of these lesio...

    A. Probst, B. H. Anderton, J. -P. Brion, J. Ulrich in Acta Neuropathologica (1989)

  6. No Access

    Chapter and Conference Paper

    A cDNA Encodes Epitopes Shared Between Microtubule-Associated Protein MAP2 and Alzheimer Neurofibrillary Tangles: In Situ Hybridization and Immunocytochemistry

    Neurofibrillary tangles in Alzheimer’s disease are composed of abnormal filaments whose biochemical composition is partly resolved. Cytoskeletal proteins are major components of these abnormal fibers, the micr...

    J. P. Brion, A. M. Couck, M. E. Cheetham… in Biological Markers of Alzheimer’s Disease (1989)

  7. No Access

    Article

    Progressive supranuclear palsy: extensive neuropil threads in addition to neurofibrillary tangles

    Light microscopic immunohistochemical investigations were performed on neurofibrillary tangles (NFT) in four histologically confirmed cases of Alzheimer's disease (AD) and in five patients with a progressive s...

    A. Probst, D. Langui, C. Lautenschlager, J. Ulrich, J. P. Brion… in Acta Neuropathologica (1988)

  8. No Access

    Article

    Alzheimer dementia and Pick's disease: neurofibrillary tangles and Pick bodies are associated with identical phosphorylated neurofilament epitopes

    Section of formaldehyde-fixed paraffinembedded cortical and hippocampal brain tissue from five cases with senile dementia of Alzheimer type (SDAT) and five cases with Pick's disease (PD) were immunostained wit...

    J. Ulrich, M. Haugh, B. H. Anderton, A. Probst, C. Lautenschlager… in Acta Neuropathologica (1987)

  9. No Access

    Article

    Staining with monoclonal antibodies to neurofilaments distinguishes between subpopulations of neurofibrillary tangles, between groups of axons and between groups of dendrites

    A new monoclonal antibody (mab) against neurofilaments is described (mab 1215) and its reactions compared with previously characterized mabs (BF10; RT97). Mab 1215 recognizes an epitope on the heavy neurofilam...

    J. Kahn, B. H. Anderton, C. C. J. Miller, J. N. Wood, M. M. Esiri in Journal of Neurology (1987)

  10. No Access

    Article

    Pick's disease: An immunocytochemical study of neuronal changes

    We used rabbit antisera to the 210,000; 155,000; and 70,000 mol. wt. neurofilament — polypeptides and monoclonal antibodies (BF 10; RT 97) known to react with human neurofilaments in an immunohistochemical stu...

    A. Probst, B. H. Anderton, J. Ulrich, R. Kohler, J. Kahn… in Acta Neuropathologica (1983)