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Article
Pyridoxamine as a multifunctional pharmaceutical: targeting pathogenic glycation and oxidative damage
The discovery that pyridoxamine (PM) can inhibit glycation reactions and the formation of advanced glycation end products (AGEs) stimulated new interest in this B6 vitamer as a prospective pharmacological agent f...
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Article
A non-mammalian in vivo model for cellular and molecular analysis of glucose-mediated thickening of basement membranes
An increase of basement membrane thickness in renal glomeruli, blood vessels, and other tissues is a consistent pathological observation in individuals with diabetes mellitus. Although a number of pathological...
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Article
Fractionation of Protein Solutions by Membrane Partition Chromatography
HIGH flux preformed ultrafiltration membranes, serving as diffusive barriers to the transport of macromolecular species, have been found to be extremely useful for: the non-denaturant concentration of dilute p...