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Article
40th EASD Annual Meeting of the European Association for the Study of Diabetes
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Article
Accelerated atherosclerosis in the transplant recipient: role of hypertension
An accelerated atherosclerosis may occur in the native arteries of a transplant recipient as well as in arteries of transplanted kidneys or hearts. The dominating cause of patient mortality are cardiovascular ...
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Article
Treatment of renal calcium stone disease with the synthetic glycosaminoglycan pentosan polysulphate
Glycosaminoglycans (GAGs) are potent inhibitors of calcium oxalate growth and aggregation. The synthetic GAG pentosan polysulphate (PPS) was used in the treatment of patients with renal calcium stone disease. ...
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Chapter
New Drugs to Prevent Recurrence of Renal Stone Disease
Many patients who are stone formers have recurrent stone formation, for which detailed clinical and biochemical work-up is necessary. Even if conventional treatments with thiazides, orthophosphate, or magnesiu...
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Chapter
Renal Calculi and Bacterial Adherence: An Ultrastructural Study of Adhesion to Hydroxyapatite Particles by Urinary Tract Pathogens
Urinary tract infections associated with renal calculi are often impossible to cure with antibiotics unless the stone is removed surgically. Calculi may be infection-induced (struvite) or may be formed in idio...
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Chapter
Glycosaminoglycans as Inhibitors of Renal Stone Formation
Renal stone formation is basically a consequence of an imbalance between supersaturation of the urine and the inhibition of crystal formation and growth. Urine contains many substances which are claimed to mod...
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Chapter
Intestinal Absorption of Oxalate and Calcium
The majority of renal stones contain calcium oxalate (1, 2). In patients with idiopathic calcium stone disease, an increased excretion of both calcium and oxalate is reported (3, 4). After jejuno-ileal bypass ...
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Chapter
The Possibility of a Specific Calcium Sensor/Receptor Function of Proximal Renal Tubular Cells
Disturbances of calcium metabolism are well documented in renal calcium-stone disease and hypercalciuria is the most commonly-occurring metabolic deviation (1). Idiopathic hypercalciuria is considered to be ca...
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Chapter and Conference Paper
Clinical characteristics of renal stone disease in relation to urinary oxalate excretion
The formation of calcium-containing renal stones is regarded as a multifactorial process involving high urinary concentrations of calcium and oxalate in combination with reduced excretion of inhibitory factors...
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Chapter and Conference Paper
The importance of residual calculi on recurrence in patients with infection stones
Traditionally the purpose in all kind of renal stone surgery is to achieve complete clearance of the kidney. It is, of course, still an important task to remove the stone fragments, although in newer operative...
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Chapter and Conference Paper
Glycosaminoglycans and renal stone disease: clinical effects of pentosan polysulphate (Elmiron)
Renal stone formation is basically a consequence of an imbalance between super-saturation of the urine and the inhibition of crystal formation and growth. Glycosaminoglycans (GAGs) including heparan sulphate, ...
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Chapter and Conference Paper
Oxalate and calcium absorption tests in patients after jejunoileal anastomosis and in idiopathic renal stone formers in comparison with healthy subjects
Calcium oxalate is the main constituent of about 60–85% of all renal stones (1–3). The concentration of calcium and oxalate in urine are major risk factors for the formation of renal stones (4). Renal excretio...
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Chapter and Conference Paper
The mechanism of glycosaminoglycan inhibition of calcium oxalate crystal growth
Urinary inhibition of crystal growth and aggregation is an important determinant for stone formation in the urinary tract along with supersaturation of the urine (1). Naturally occurring inhibitors such as pyr...
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Chapter and Conference Paper
Heredity, Serum Phosphate and Urinary Calcium in Calcium Urolithiasis
Familial patterns of renal calcium stone disease have been reported1,2. Familial hypercalciuria has also been described3. The question as to whether or not other risk factors besides urinary calcium are inherited...
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Chapter and Conference Paper
Phosphate Treatment of Calcium Urolithiasis
Dietary supplementation with orthophosphate was proposed as an alternative for prophylaxis of renal stone formation many years ago1. The rationale for this proposal is the documented effect of phosphates on reduc...
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Chapter and Conference Paper
Allopurinol Treatment in Urolithiasis
A large number of prophylactic treatments have been used to prevent stone formation in the urinary tract. Treatment with orthophosphate, thiazides and magnesium hydroxide have been shown to be effective in pre...
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Chapter and Conference Paper
Stone Analysis and Urinary Tract Infection in Renal Stone Patients
The influence of bacterial urease in the calculogenesis of struvite and apatite calculi is well known1−4. The significance of urinary tract infection (UTI) among other stone formers and its relationship to the ty...
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Chapter and Conference Paper
Inhibition of uric acid crystal adherence by bladder surface and urinary glycosaminoglycans
Bladder surface glycosaminoglycan (GAG) has been shown to act in a non-specific manner as an antiadherence factor and may potentially be important in the pathogenesis and prevention of renal calculi (1). It ha...
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Chapter and Conference Paper
Crystal Inhibition:Binding of Heparin and Chondroitin Sulphate to Calcium Oxalate, Sodium Urate and Uric Acid Crystals
Urinary glycosaminoglycans may be important inhibitors of calcium oxalate crystal growth and aggregation1. These inhibitors may act by blocking the growth sites of the crystals and thereby prevent or delay crysta...
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Chapter and Conference Paper
Gel Filtration of Concentrated Urine: the Relation Between Calcium Oxalate Crystal Growth Inhibition and Glycosaminoglycan Chromatograms
Macromolecular urinary constituents have been suggested to be important inhibitors of calcium oxalate crystal growth and aggregation. Glycosaminoglycans have been most widely investigated and shown to inhibit ...
