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Article
Open AccessVoxel-based map** of grey matter volume and glucose metabolism profiles in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive disease of the nervous system involving both upper and lower motor neurons. The patterns of structural and metabolic brain alterations are still unc...
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Article
Pathophysiology of the behavioral variant of frontotemporal lobar degeneration: A study combining MRI and FDG-PET
Gray matter (GM) lobar atrophy and glucose hypometabolism are well-described hallmarks of frontotemporal lobar degeneration (FTLD), but the relationships between them are still poorly understood. In this study...
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Chapter
Cognition et imagerie cérébrale : contrastes entre vieillissement normal et maladie d’Alzheimer
La maladie d’Alzheimer (MA) est parfois présentée comme une « accélération du vieillissement normal » et le concept de MCI (pour Mild Cognitive Impairment), tout du moins le MCI amnésique, compris comme un état i...
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Article
Open AccessUsing PET with 18F-AV-45 (florbetapir) to quantify brain amyloid load in a clinical environment
Positron emission tomography (PET) imaging of brain amyloid load has been suggested as a core biomarker for Alzheimer’s disease (AD). The aim of this study was to test the feasibility of using PET imaging with 18
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Chapter and Conference Paper
Mild Cognitive Impairment (MCI): Predicting Conversion to Clinically Probable Alzheimer’s Disease with Fluoro-Deoxy-Glucose PET
Optimal implementation of disease-modifying treatment for sporadic Alzheimer’ s disease (AD) will require detection of patients at the pre-dementia stage. Resting-state map** of brain glucose utilization wit...
