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Article
High target attainment for β-lactam antibiotics in intensive care unit patients when actual minimum inhibitory concentrations are applied
Patients in the intensive care unit (ICU) are at risk for suboptimal levels of β-lactam antibiotics, possibly leading to poor efficacy. Our aim was to investigate whether the actual minimum inhibitory concentr...
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Article
Neutron and weak-charge distributions of the 48Ca nucleus
What is the size of the atomic nucleus? This deceivably simple question is difficult to answer. Although the electric charge distributions in atomic nuclei were measured accurately already half a century ago, ...
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Article
Influence of CYP2D6 and CYP2C19 genotypes on venlafaxine metabolic ratios and stereoselective metabolism in forensic autopsy cases
We investigated whether polymorphisms in the CYP2D6 and CYP2C19 genes influence the metabolic ratios and enantiomeric S/R ratios of venlafaxine (VEN) and its metabolites O-desmethylvenlafaxine (ODV), N-desmethylv...
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Chapter
Potential Fields in Modeling Transport over Water
Without an explicit road-like regulation, following the proper sailing routes and practices is still a challenge mostly addressed using seamen’s know-how and experience. This chapter focuses on the problem of ...
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Article
ABCB1 gene polymorphisms are associated with fatal intoxications involving venlafaxine but not citalopram
P-glycoprotein (P-gp), encoded by the ABCB1/MDR1 gene, is a drug transporter at the blood–brain barrier. Several polymorphisms in the ABCB1 gene are known to affect the activity and/or expression of P-gp, thereby...
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Article
Erratum: Associations of markers in 11 obesity candidate genes with maximal weight loss and weight regain in the SOS bariatric surgery cases
Correction to: International Journal of Obesity (2011) 35, 676–683; doi:10.1038/ijo.2010.166 Sarzynski et al.1 reported the association of obesity candidate genes with weight loss and regain after bariatric su...
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Article
Associations of markers in 11 obesity candidate genes with maximal weight loss and weight regain in the SOS bariatric surgery cases
To test whether DNA sequence variation in 11 obesity genes is associated with maximum weight loss and weight regain over 6 years of follow-up in bariatric surgery patients of the Swedish obese subjects (SOS) i...
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Article
Uso dell’analogo degli ormoni tiroidei eprotirome associato alle statine nella dislipidemia
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Chapter
Climate change and water resources in Sweden — analysis of uncertainties
Simulations of the impacts of climate change on water resources in Sweden are produced within the Swedish Regional Climate Modelling Programme, SWECLIM. The impact studies are based on a combination of global ...
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Article
Optimization and characterization of the chiral separation of citalopram and its demethylated metabolites by response-surface methodology
Response-surface modelling and sequential optimization have been used for optimization and characterization of the separation of the enantiomers of citalopram, desmethylcitalopram, and didesmethylcitalopram on...
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Chapter
Climate and Hydrology of the Baltic Basin
Due to its semi-enclosed character the Baltic Sea is very vulnerable to pollution and its environmental status is a major concern for the northern European countries. The water body is affected by contribution...
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Article
Truncating ribosomal protein S19 mutations and variable clinical expression in Diamond-Blackfan anemia
Diamond-Blackfan anemia (DBA) is a rare constitutional erythroblastopenia characterized by a specific defect in erythroid differentiation. Recently, mutations in the gene encoding ribosomal protein (RP) S19 w...
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Article
Low-dose aspirin decreases blood alcohol concentrations by delaying gastric emptying
Objective: To determine if treatment with low-dose aspirin (ASA) influences the bioavailability of orally administered alcohol and to assess whether this is caused by altered gastric emptying as measured by the ...
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Article
Growth failure, encephalopathy, and endocrine dysfunctions in two siblings, one with 5-oxoprolinase deficiency
Two female siblings, born to consanguineous parents, presented with a similar phenotype characterized by severe growth and developmental failure, dysmorphic features, thyroïd and gonadal dysfunction, autistic...
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Article
Durability assessment of automotive coatings—Design and evaluation of accelerated tests
In this work the influence of different climatic parameters on the rate of gloss reduction was studied for a number of different automotive coatings. The purpose was to improve the reliability of accelerated t...
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Chapter and Conference Paper
A Simple Method for Determining the Anisotropic Properties of Cold Drawn Wire
Metal wire produced by cold drawing often shows a high degree of anisotropy. If the wire is formed plastically after the drawing operation, the anisotropy will influence the deformation and the final geometry ...
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Chapter
The Effect of Caloric Supplementation on Levels of Milk IgA Antibodies and Their Avidities in Undernourished Guatemalan Mothers
Undernutrition affects the immune response and, therefore, might worsen the outcome of infections.1,2 This is especially important in develo** countries where the prevalence of infectious diseases is high.
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Article
5-Oxoprolinuria associated with 5-oxoprolinase deficiency; further evidence that this is a benign disorder
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Article
Prenatal analysis in two suspected cases of glutathione synthetase deficiency
Prenatal diagnosis was performed in a family affected by generalized glutathione synthetase deficiency. The disorder is transmitted by autosomal recessive inheritance. The first child born in this family died ...
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Article
Fast chromatographic separation of (−)-menthyl chloroformate derivatives of some chiral drugs, with special reference to amlodipine, on porous graphitic carbon
Enantiomeric separation of (−)-menthyl chloroformate derivatives of some chiral cardioactive drugs, on porous graphitic carbon (PGC), Hypercarb-S, is described. Capacity and separation factors of derivatives o...
