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Open AccessImmune microenvironment characterisation and dynamics during anti-HER2-based neoadjuvant treatment in HER2-positive breast cancer
Despite their recognised role in HER2-positive (HER2+) breast cancer (BC), the composition, localisation and functional orientation of immune cells within tumour microenvironment, as well as its dynamics durin...
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Open AccessCombination of phenotype and polygenic risk score in breast cancer risk evaluation in the Spanish population: a case –control study
In recent years, the identification of genetic and phenotypic biomarkers of cancer for prevention, early diagnosis and patient stratification has been a main objective of research in the field. Different multi...
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A retrospective, multicenter study of the efficacy of lapatinib plus trastuzumab in HER2-positive metastatic breast cancer patients previously treated with trastuzumab, lapatinib, or both: the Trastyvere study
To evaluate the efficacy and safety of lapatinib (L) and trastuzumab (T) combination in HER2-positive metastatic breast cancer (MBC) patients previously treated with T and/or L.
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Evolution of older patients diagnosed with early breast cancer in Spain between 1998 and 2001 included in El Alamo III project
An increase in the number of cancer cases is expected in the near future. Breast cancer (BC) mortality rates increase with age even when adjusted for other variables. Here we analyzed BC disease-free survival ...
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Influence of different treatment techniques and clinical factors over the intrafraction variation on lung stereotactic body radiotherapy
In the present study we compared three different Stereotactic body radiation therapy (SBRT) treatment delivery techniques in terms of treatment time (TT) and their relation with intrafraction variation (IFV). ...
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Open AccessSEOM clinical guidelines in early-stage breast cancer 2015
Breast cancer is a major public health problem. Despite remarkable advances in early diagnosis and treatment, one in three women may have metastases since diagnosis. Better understanding of prognostic and pred...
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Open AccessRetrospective analysis of the use of G-CSF and its impact on dose response for anthracycline plus taxane-based schedules in early breast cancer
To evaluate the impact on survival of the relative dose intensity (RDI) achieved in patients with early breast cancer receiving anthracycline plus taxane-based chemotherapy in the adjuvant setting.
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Laparoscopic myotomy vs endoscopic dilation in the treatment of achalasia
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Gas exchange and pulmonary haemodynamic responses to fat emulsions in acute respiratory distress syndrome
To investigate the gas exchange and pulmonary haemodynamic responses to two different intravenous fat emulsions in patients with acute respiratory distress syndrome (ARDS).
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Severe acute pancreatitis: treatment with somatostatin
Objective: To investigate the efficacy of somatostatin for the treatment of severe acute pancreatitis. Design: Prospective, randomized and unblinded study. Setting: A general intensive care unit ...
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The Acidic Ribosomal Proteins and the Control of Protein Synthesis in Yeast
The protein L7/12 of the large bacterial ribosomal subunit, is unique among the components of the particle due to its strongly acidic pI and to the fact that it is the only multicopy components of the bacteria...
