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  1. Article

    Open Access

    Identification of RIP1 as a critical mediator of Smac mimetic-mediated sensitization of glioblastoma cells for Drozitumab-induced apoptosis

    This study aims at evaluating the combination of the tumor-necrosis-factor-related apoptosis-inducing ligand (TRAIL)-receptor 2 (TRAIL-R2)-specific antibody Drozitumab and the Smac mimetic BV6 in preclinical g...

    S Cristofanon, B A Abhari, M Krueger, A Tchoghandjian, S Momma… in Cell Death & Disease (2015)

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  2. Article

    Open Access

    NIK is required for NF-κB-mediated induction of BAG3 upon inhibition of constitutive protein degradation pathways

    Recently, we reported that induction of the co-chaperone Bcl-2-associated athanogene 3 (BAG3) is critical for recovery of rhabdomyosarcoma (RMS) cells after proteotoxic stress upon inhibition of the two consti...

    F Rapino, B A Abhari, M Jung, S Fulda in Cell Death & Disease (2015)

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  3. Article

    Open Access

    Pretubulysin: a new option for the treatment of metastatic cancer

    Tubulin-binding agents such as taxol, vincristine or vinblastine are well-established drugs in clinical treatment of metastatic cancer. However, because of their highly complex chemical structures, the synthes...

    S Braig, R M Wiedmann, J Liebl, M Singer, R Kubisch, L Schreiner… in Cell Death & Disease (2014)

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  4. No Access

    Article

    RIP1 is required for IAP inhibitor-mediated sensitization for TRAIL-induced apoptosis via a RIP1/FADD/caspase-8 cell death complex

    Inhibitor of apoptosis (IAP) proteins represent promising therapeutic targets due to their high expression in many cancers. Here, we report that small-molecule IAP inhibitors at subtoxic concentrations coopera...

    B A Abhari, S Cristofanon, R Kappler, D von Schweinitz, R Humphreys, S Fulda in Oncogene (2013)

  5. No Access

    Article

    Histone deacetylase inhibitors sensitize glioblastoma cells to TRAIL-induced apoptosis by c-myc-mediated downregulation of cFLIP

    Glioblastoma is the most common primary brain tumor with a very poor prognosis, calling for novel treatment strategies. Here, we provide first evidence that histone deacetylase inhibitors (HDACI) prime gliobla...

    A Bangert, S Cristofanon, I Eckhardt, B A Abhari, S Kolodziej, S Häcker… in Oncogene (2012)