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  1. Article

    Open Access

    Use of broad-spectrum antimicrobials for more than 72 h and the detection of multidrug-resistant bacteria in Japanese intensive care units: a multicenter retrospective cohort study

    Large multicenter studies reporting on the association between the duration of broad-spectrum antimicrobial administration and the detection of multidrug-resistant (MDR) bacteria in the intensive care unit (IC...

    Hideki Yoshida, Takako Motohashi… in Antimicrobial Resistance & Infection Contr… (2022)

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  2. Article

    Open Access

    In-situ preservation of nitrogen-bearing organics in Noachian Martian carbonates

    Understanding the origin of organic material on Mars is a major issue in modern planetary science. Recent robotic exploration of Martian sedimentary rocks and laboratory analyses of Martian meteorites have bot...

    Mizuho Koike, Ryoichi Nakada, Iori Kajitani, Tomohiro Usui… in Nature Communications (2020)

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  3. Article

    Open Access

    Comparison of the efficacy of three topical antiseptic solutions for the prevention of catheter colonization: a multicenter randomized controlled study

    To compare the efficacy of three antiseptic solutions [0.5%, and 1.0% alcohol/chlorhexidine gluconate (CHG), and 10% aqueous povidone-iodine (PVI)] for the prevention of intravascular catheter colonization, we...

    Hideto Yasuda, Masamitsu Sanui, Takayuki Abe, Nobuaki Shime… in Critical Care (2017)

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  4. No Access

    Article

    lynx1 Supports Neuronal Health in the Mouse Dorsal Striatum During Aging: an Ultrastructural Investigation

    Nicotinic acetylcholine receptors have been shown to participate in neuroprotection in the aging brain. Lynx protein modulators dampen the activity of the cholinergic system through direct interaction with nic...

    Atsuko Kobayashi, Rell L. Parker, Ashley P. Wright… in Journal of Molecular Neuroscience (2014)

  5. Article

    Effects of adherence to ventilator-associated pneumonia treatment guidelines on clinical outcomes

    Two guidelines are currently available to guide Japanese clinicians caring for patients with ventilator-associated pneumonia (VAP): the 2005 American Thoracic Society/Infectious Diseases Society of America (AT...

    Masahiro Sakaguchi, Nobuaki Shime, Naoya Iguchi… in Journal of Infection and Chemotherapy (2013)

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  6. Article

    Open Access

    COPD and disease-specific health status in a working population

    It has been debated whether treatment should be started early in subjects with mild to moderate COPD. An impaired health status score was associated with a higher probability of being diagnosed with COPD as co...

    Koichi Nishimura, Satoshi Mitsuma, Atsuko Kobayashi… in Respiratory Research (2013)

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  7. No Access

    Article

    Early recovery in hemodynamics after direct hemoperfusion with polymyxin B-immobilized fibers may predict mortality rate in patients with septic shock

    This retrospective and observational study attempted to determine whether the rapid improvement in hemodynamic parameters and the subsequent discontinuation or decrease of catecholamine infusion shortly after ...

    Atsuko Kobayashi, Yasushi Iwasaki, Yuichi Kimura, Yoshiaki Kawagoe… in Journal of Anesthesia (2010)

  8. No Access

    Article

    Severe Legionella pneumophila pneumonia associated with the public bath on a cruise ship in Japan

    Atsuko Kobayashi, Yoshifumi Yamamoto, Sumito Chou… in Journal of Anesthesia (2004)

  9. No Access

    Article

    Clinical Pharmacokinetics and Pharmacodynamics of Glyceryl Trinitrate and its Metabolites

    This review discusses the pharmacokinetics and pharmacodynamics of glyceryl trinitrate (nitroglycerin; GTN) pertinent to clinical medicine. The pharmacokinetics of GTN associated with various dose regimens are...

    Dr Satoru Hashimoto, Atsuko Kobayashi in Clinical Pharmacokinetics (2003)

  10. No Access

    Article

    Growth of Pd particles in methanol synthesis over Pd/CeO2

    The metal–support contact structure of Pd–CeO2 changed with increasing the temperature of reduction. Upon high temperature reduction, severe sintering of Pd particles occurred, while sintering of the ceria suppor...

    Wen-Jie Shen, Atsuko Kobayashi, Yuichi Ichihashi, Yasuyuki Matsumura… in Catalysis Letters (2001)

  11. Article

    Autonomic hyperreflexia during labour

    We present two cases of automatic hyperreflexia (AH) during labour in women with spinal cord damage, in whom AH developed before and after delivery. The AH was successfully controlled using epidural anaesthesi...

    Atsuko Kobayashi, Toshiki Mizobe, Hideaki Tojo… in Canadian Journal of Anaesthesia (1995)

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  12. No Access

    Article

    Effects of prostaglandin E1 on renal hemodynamics

    The glomerular filtration rate (GFR), renal plasma flow (RPF), renal blood flow (RBF), filtration fraction (FF), and the ratio of mean arterial pressure (MAP) to RBF (MAP/RBF), reflecting renal vascular resist...

    Atsuko Kobayashi in Journal of Anesthesia (1994)

  13. No Access

    Article

    Change in growth kinetics of hybridoma cells entrapped in collagen gel affected by alkaline supply

    The growth yields for glucose and glutamine of murine hybridoma cells entrapped in collagen gel particles were examined during the growth phase. The immobilized hybridoma cells were cultivated in a fluidized b...

    Yoshihito Shirai, Masaaki Yamaguchi, Atsuko Kobayashi, Akihiro Nishi… in Cytotechnology (1994)

  14. No Access

    Article

    Pulmonary edema induced by laryngospasm

    Atsuko Kobayashi, Rokurou Shiba, Mitsuyoshi Lee, Yoshifumi Tanaka in Journal of Anesthesia (1993)

  15. No Access

    Article

    Recurrence of asthma after removal of adrenaline secreting pheochromocytoma

    Atsuko Kobayashi, Toyoshi Hosokawa, Yoshifumi Tanaka in Journal of Anesthesia (1993)