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Article
Prenatal alcohol exposure and adverse fetal growth restriction: findings from the Japan Environment and Children’s Study
Japanese studies on the association between maternal alcohol consumption and fetal growth are few. This study assessed the effect of maternal alcohol consumption on fetal growth.
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Article
Open AccessAssociations among perfluorooctanesulfonic/perfluorooctanoic acid levels, nuclear receptor gene polymorphisms, and lipid levels in pregnant women in the Hokkaido study
The effect of interactions between perfluorooctanesulfonic (PFOS)/perfluorooctanoic acid (PFOA) levels and nuclear receptor genotypes on fatty acid (FA) levels, including those of triglycerides, is not clear u...
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Article
Mediating Factors Between Parental Socioeconomic Status and Small for Gestational Age in Infants: Results from the Hokkaido Study on Environment and Children’s Health
Previous studies indicated a significant association between small for gestational age (SGA) in infants and their parents' socioeconomic status (SES). Thus, this study aimed to examine if parental factors, suc...
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Article
Open AccessLifestyle behaviors and home and school environment in association with sick building syndrome among elementary school children: a cross-sectional study
Sick building syndrome (SBS) refers to the combination of symptoms experienced by occupants of specific building characteristics. This study investigated the associations of children’s lifestyle behaviors, all...
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Chapter
Early-Life Environmental Influences on Allergic Diseases
Allergic diseases, including asthma, food allergies, atopic dermatitis (eczema), allergic rhinitis or hay fever, and anaphylaxis, have gradually been increasing in prevalence. Allergies have both a genetic and...
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Chapter
Importance of Indoor Environmental Quality on Human Health toward Achievement of the SDGs
In modern days, particularly in urban areas, people may spend more time indoors. Thus, a healthy indoor environment is key for healthy living. The concept of “sick building syndrome (SBS)” refers to nonspecifi...
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Chapter
Endocrine-Distributing Chemicals and Reproductive Function
Exposures to environmental chemicals affecting androgen action (endocrine-disrupting chemicals (EDCs)) are suspected to have a negative impact on male reproductive function by disrupting normal differentiation...
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Chapter
Aldehydes, Volatile Organic Compounds (VOCs), and Health
A variety of organic compounds are found in the indoor air. Aldehydes and volatile organic compounds (VOCs) are chemicals categorized with boiling points from 50–100 °C to 240–260 °C; therefore, they can be fo...
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Chapter
Further Direction of Research and Policy Making of Environment and Children’s Health
The Minamata Convention was established following the Minamata disaster. To protect humans and the environment from persistent organic pollutants, the Stockholm Convention was established. However, there are m...
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Article
Open AccessPrenatal tobacco exposure and ADHD symptoms at pre-school age: the Hokkaido Study on Environment and Children’s Health
There have been inconsistent findings reported on maternal passive smoking during pregnancy and child risk of ADHD. In this study, ADHD symptoms at pre-school age children in association with prenatal passive ...
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Article
Open AccessAn epigenome-wide analysis of cord blood DNA methylation reveals sex-specific effect of exposure to bisphenol A
Exposure to bisphenol A (BPA) in utero is associated with adverse health outcome of the offspring. Differential DNA methylation at specific CpG sites may link BPA exposure to health impacts. We examined the assoc...
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Article
Open AccessFor making a declaration of countermeasures against the falling birth rate from the Japanese Society for Hygiene: summary of discussion in the working group on academic research strategy against an aging society with low birth rate
In 1952, the Japanese Society for Hygiene had once passed a resolution at its 22nd symposium on population control, recommending the suppression of population growth based on the idea of cultivating a healthie...
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Chapter
The Hokkaido Study on Environment and Children’s Health
The Hokkaido Study on Environment and Children’s Health is an ongoing study of two birth cohorts: the Sapporo cohort and the Hokkaido cohort. Our primary goals are (1) to examine the possible effects of low-le...
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Article
Open AccessPrenatal exposure to bisphenol A and phthalates and behavioral problems in children at preschool age: the Hokkaido Study on Environment and Children’s Health
Studies reported adverse behavioral development including internalizing and externalizing problems in association with prenatal exposure to bisphenol A (BPA) and phthalates; however, findings were not sufficie...
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Article
Open AccessAssociation between DNA methylation in cord blood and maternal smoking: The Hokkaido Study on Environment and Children’s Health
Maternal smoking is reported to cause adverse effects on the health of the unborn child, the underlying mechanism for which is thought to involve alterations in DNA methylation. We examined the effects of mate...
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Article
Open AccessThe Hokkaido Birth Cohort Study on Environment and Children’s Health: cohort profile—updated 2017
The Hokkaido Study on Environment and Children’s Health is an ongoing study consisting of two birth cohorts of different population sizes: the Sapporo cohort and the Hokkaido cohort. Our primary study goals ar...
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Article
Effects of prenatal perfluoroalkyl acid exposure on cord blood IGF2/H19 methylation and ponderal index: The Hokkaido Study
Prenatal exposure to perfluoroalkyl acids (PFAAs) influences fetal growth and long-term health. However, whether PFAAs affect offspring DNA methylation patterns to influence health outcomes is yet to be evalua...
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Article
Prenatal maternal blood triglyceride and fatty acid levels in relation to exposure to di(2-ethylhexyl)phthalate: a cross-sectional study
The hypolipidemic effects of di(2-ethylhexyl)phthalate (DEHP) exposure in humans have not been investigated. And the influences of maternal prenatal DEHP exposure on birth outcomes are not well-known. We aime...
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Article
Ten years of progress in the Hokkaido birth cohort study on environment and children’s health: cohort profile—updated 2013
The Hokkaido Study on Environment and Children’s Health is an ongoing cohort study that began in 2002. The study consists of two prospective birth cohorts, the Sapporo cohort (n = 514) and the Hokkaido large-scal...
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Article
The relationship between atopic dermatitis and indoor environmental factors: a cross-sectional study among Japanese elementary school children
This study aimed to determine that home environmental factors were associated with atopic dermatitis in Japanese elementary school children.
