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  1. No Access

    Article

    Head-to-Head Comparison of CCN4, DNMT3A, PTPN11, and SPARC as Suppressors of Anti-tumor Immunity

    Emergent cancer cells likely secrete factors that inhibit anti-tumor immunity. To identify such factors, we applied a functional assay with proteomics to an immunotherapy resistant syngeneic mouse melanoma mod...

    Anika C. Pirkey, Wentao Deng, Danielle Norman… in Cellular and Molecular Bioengineering (2023)

  2. Article

    Open Access

    Data-driven learning how oncogenic gene expression locally alters heterocellular networks

    Develo** drugs increasingly relies on mechanistic modeling and simulation. Models that capture causal relations among genetic drivers of oncogenesis, functional plasticity, and host immunity complement wet e...

    David J. Klinke II, Audry Fernandez, Wentao Deng, Atefeh Razazan… in Nature Communications (2022)

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  3. Article

    Open Access

    Lambda bacteriophage nanoparticles displaying GP2, a HER2/neu derived peptide, induce prophylactic and therapeutic activities against TUBO tumor model in mice

    Generating a protective and long-lasting immune response is the primary goal in the expanding field of immunotherapeutic research. In current study we designed an immunogenic bacteriophage- based vaccine to in...

    Atefeh Razazan, Jessica Nicastro, Roderick Slavcev, Nastaran Barati… in Scientific Reports (2019)

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  4. No Access

    Article

    Lambda phage nanoparticles displaying HER2-derived E75 peptide induce effective E75-CD8+ T response

    We have investigated the in vitro immunogenicity and in vivo prophylactic and therapeutic potential of lambda (λ) phage particles displaying the E75 peptide (derived from HER2 protein) in an implantable TUBO b...

    Atefeh Arab, Jessica Nicastro, Roderick Slavcev, Atefeh Razazan… in Immunologic Research (2018)