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Article
Open AccessEpCAM-positive circulating tumor cells and serum AFP levels predict outcome after curative resection of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) has high recurrence rates exceeding 50% despite curative resection. The serum biomarker alpha-fetoprotein (AFP) is a well-known prognostic marker for HCC. EpCAM-positive circulat...
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Chapter
Individualisierte Pankreaschirurgie
Dieses Kapitel enthält eine Beschreibung der technischen Schritte von duodenumerhaltender Pankreaskopfresektion, Papillenresektion, Operation nach Whipple sowie zentraler und distaler Pankreasresektion, die in...
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Article
Open AccessHepatocellular carcinoma: Intratumoral EpCAM-positive cancer stem cell heterogeneity identifies high-risk tumor subtype
The translational interest in the intratumoral heterogeneity of hepatocellular carcinoma (HCC) has been increasing. The dismal prognosis of this pathology is linked to the features of the HCC harbouring cancer...
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Article
Letter to Editor Reply to: “Centralization of Pancreatic Surgery in Europe: an Update”
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Article
Open AccessHigh-level expression of protein tyrosine phosphatase non-receptor 12 is a strong and independent predictor of poor prognosis in prostate cancer
Protein tyrosine phosphatase non-receptor 12 (PTPN12) is ubiquitously tyrosine phosphatase with tumor suppressive properties.
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Article
Successful Use of the Recanalized Remnant Umbilical Vein as a Patch Graft for Venous Reconstruction in Abdominal Surgery
Various approaches have been described for the reconstruction of the portal vein (PV), superior mesenteric vein (SMV), and the inferior vena cava (IVC). We present the use of the recanalized remnant umbilical ...
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Article
Open AccessFOXO1 overexpression and loss of pSerine256-FOXO1 expression predicts clinical outcome in esophageal adenocarcinomas
The function of Forkhead box O 1 (FOXO1) and pSerine256-FOXO1 immunostaining in esophageal cancer is unclear. To clarify the prognostic role of nuclear FOXO1 and cytoplasmic pSerine256-FOXO1 immunostaining, a ...
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Article
Open AccessMinimally invasive surgery for colorectal cancer remains underutilized in Germany despite its nationwide application over the last decade
Minimally invasive surgery (MIS) has superior short-term outcomes than open surgery (OS) for colorectal cancer (CRC). However, a nationwide dataset has not been analysed to confirm these findings. We evaluated...
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Article
Open AccessAuthor Correction: Up regulation and nuclear translocation of Y-box binding protein 1 (YB-1) is linked to poor prognosis in ERG-negative prostate cancer
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
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Article
Open AccessPSCA expression is associated with favorable tumor features and reduced PSA recurrence in operated prostate cancer
Prostate Stem Cell Antigen (PSCA) is frequently expressed in prostate cancer but its exact function is unclear.
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Article
Open AccessHigh BCAR1 expression is associated with early PSA recurrence in ERG negative prostate cancer
Breast cancer anti-estrogen resistance 1 (BCAR1/p130cas) is a hub for diverse oncogenic signaling cascades and promotes tumor development and progression.
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Article
CD151 expression is frequent but unrelated to clinical outcome in head and neck cancer
CD151 is a plasma membrane protein belonging to the tetraspanin family. CD151 represents a putative therapeutic target and has been suggested as a prognostic marker in several cancer types. The present study a...
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Article
Open AccessUp regulation and nuclear translocation of Y-box binding protein 1 (YB-1) is linked to poor prognosis in ERG-negative prostate cancer
Y-box binding protein 1 (YB-1) is an RNA and DNA binding factor with potential prognostic cancer. To evaluate the clinical impact of YB-1, a tissue microarray with 11,152 prostate cancers was analysed by immun...
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Article
p16 upregulation is linked to poor prognosis in ERG negative prostate cancer
Altered expression of the p16 tumor suppressor is frequently found in prostate cancer, but its role for tumor development and patient prognosis is disputed. In order to clarify the prognostic role of p16 and t...
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Article
How we do it: double in situ split for staged mesohepatectomy in patients with advanced gall bladder cancer and marginal future liver remnant
Associating liver partition with portal vein ligation for staged hepatectomy (ALPPS) has increased the rate of liver resections in patients with marginal future liver remnant. We here describe a modified ALPPS...
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Chapter and Conference Paper
Charakterisierung nichtdendritischer monozytärer Zellen mit immunregulatorischen Eigenschaften
The concept of actively acquired immune tolerance was first shown by the group of Medawar in 1953. Over the past few years, many new insights in the process of immune regulation have been gained. In 1995, Saka...
