Skip to main content

9 Result(s)

within Asif Husain Remove this filter Pharmacology/Toxicology Remove this filter

and

  1. No Access

    Article

    Design and synthesis of butenolide-based amide derivatives as anti-inflammatory agents

    Butenolide-based eighteen new amide derivatives (1–18) have been synthesized and evaluated for anti-inflammatory activity. The compounds 9, 17 and 4 exhibited significant in vivo inhibition of 84.69, 76.52 and 76...

    Yakub Ali, Mohammad Sarwar Alam, Hinna Hamid, Asif Husain… in Medicinal Chemistry Research (2015)

  2. No Access

    Article

    Synthesis, characterization, in vitro antimicrobial, and anthelmintic evaluations of 2-(4-chloro-3-methylphenoxy)-N′-[{5′-(substituted aryl)-furan-2′-yl}-methylidene]-acetohydrazides

    In the present study, a novel series of 2-(4-chloro-3-methylphenoxy)-N′-[{5′-(substituted aryl)-furan-2′-yl}-methylidene]-acetohydrazides (4a–k) have been designed and synthesized with a new class of p-chloro-m-...

    Munendra Mohan Varshney, Asif Husain, Versha Parcha in Medicinal Chemistry Research (2014)

  3. No Access

    Article

    Essential aminoacid incorporated GABA–phthalimide derivatives: synthesis and anticonvulsant evaluation

    A series of novel N-(2-(benzylamino)-1-substituted-2-oxoethyl)-4-(1,3-dioxoisoindolin-2-yl)butanamide derivatives were synthesized unifying the functionalized amino acid unit and GABA–phthalimide moiety with esse...

    Priya Ahuja, Asif Husain, Nadeem Siddiqui in Medicinal Chemistry Research (2014)

  4. No Access

    Article

    Synthesis, biological activities, and pharmacokinetics studies of a mutual prodrug of aceclofenac and paracetamol

    An ester-based mutual prodrug (aceclofenac–paracetamol; AC-PR) was synthesized (one-pot method) with an aim of improving the therapeutic index through prevention of gastrointestinal irritation and bleeding tha...

    Asif Husain, Priyanka Ahuja, M. Shaharyar, Aftab Ahmad… in Medicinal Chemistry Research (2014)

  5. No Access

    Article

    Docking studies on butenolide derivatives as Cox-II inhibitors

    To supplement hits from a high through put screening, a docking study on butenolides derivatives was performed as COX-II inhibitors. The fourteen ligands were docked inside the ligand-binding domain (LBD) of p...

    Sukhbir Lal Khokra, Jyoti Monga, Asif Husain, Mohit Vij… in Medicinal Chemistry Research (2013)

  6. No Access

    Article

    Pharmacophore modeling studies on N-hydroxyphenyl acrylamides and N-hydroxypyridin-2-yl-acrylamides as inhibitor of human cancer leukemia K562 cells

    In order to understand the essential structural features for inhibitors of human cancer leukemia K562 cells, three-dimensional pharmacophore hypotheses were built on the basis of a set of inhibitors of human c...

    Jyoti Monga, Sukhbir L. Khokra, Asif Husain in Medicinal Chemistry Research (2013)

  7. No Access

    Article

    Synthesis and antimicrobial activity of bischalcone derivatives

    Several bischalcones (2a–h and 5a–e) and flavones (3a–f) were synthesized and evaluated for their antimicrobial actions. Bischalcones were prepared by condensing 1,1′-(4,6-dimethyl-1,3-phenylene)diethanone (1) or...

    Asif Husain, Aftab Ahmad, Ibraheem Ahmed I. Mkhalid… in Medicinal Chemistry Research (2013)

  8. No Access

    Article

    Quinolone derivatives as antitubercular drugs

    New chemotherapeutic drugs are the need to improve tuberculosis (TB) control particularly due to the emergence of multidrug-resistant strains and extensively drug-resistant strains of TB. These antitubercular ...

    Mohammad Asif, Anees A. Siddiqui, Asif Husain in Medicinal Chemistry Research (2013)

  9. No Access

    Article

    Studies on fused heterocyclic 3,6-disubstituted-1,2,4-triazolo-1,3,4-thiadiazoles: synthesis and biological evaluation

    In this study, a series of 3,6-disubstituted-1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazoles (5a–t) were synthesized by condensing 4-amino-3-mercapto-(4H)-1,2,4-triazoles (4a–c) with different aromatic or aroyl acids t...

    Asif Husain, Md. Arif Naseer in Medicinal Chemistry Research (2011)