31 Result(s)
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Ashish Ranjan Sharma
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Article
Open AccessAccelerated full-thickness skin wound tissue regeneration by self-crosslinked chitosan hydrogel films reinforced by oxidized CNC-AgNPs stabilized Pickering emulsion for quercetin delivery
The non-toxic self-crosslinked hydrogel films designed from biocompatible materials allow for controlled drug release and have gathered remarkable attention from healthcare professionals as wound dressing mate...
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Article
Structural Landscape of nsp Coding Genomic Regions of SARS-CoV-2-ssRNA Genome: A Structural Genomics Approach Toward Identification of Druggable Genome, Ligand-Binding Pockets, and Structure-Based Druggability
SARS-CoV-2 has a single-stranded RNA genome (+ssRNA), and synthesizes structural and non-structural proteins (nsps). All 16 nsp are synthesized from the ORF1a, and ORF1b regions associated with different life ...
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Article
Recent Advancements in the Therapeutic Development for Marburg Virus: Updates on Clinical Trials
We aim to provide valuable insights into the current state of therapeutic development for the deadly Marburg virus and guide researchers and clinicians to study the emerging therapies and shape future directio...
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Article
Exploring the status of global terrestrial and aquatic microbial diversity through ‘Biodiversity Informatics’
Biological scientists have established ‘Biodiversity Informatics’ to map the global diversity of biological organisms by using cutting-edge bioinformatics tools. This review depicts an overview of microbial di...
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Article
Advances in Computational and Bioinformatics Tools and Databases for Designing and Develo** a Multi-Epitope-Based Peptide Vaccine
A vaccine is defined as a biologic preparation that trains the immune system, boosts immunity, and protects against a deadly microbial infection. They have been used for centuries to combat a variety of contag...
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Article
Delta variant (B.1.617.2) of SARS-CoV-2: current understanding of infection, transmission, immune escape, and mutational landscape
The Delta variant is one of the alarming variants of the SARS-CoV-2 virus that have been immensely detrimental and a significant cause of the prolonged pandemic (B.1.617.2). During the SARS-CoV-2 pandemic from...
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Article
Evolution, epidemiology, geographical distribution, and mutational landscape of newly emerging monkeypox virus
Recent monkeypox (MPX) outbreaks are major ones in non-endemic countries. The present study analyzed molecular phylogenetics, divergence, epidemiology, the geographical distribution, entropy diversity of genom...
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Article
Open AccessRecent advances of metal-based nanoparticles in nucleic acid delivery for therapeutic applications
Recent efforts in designing nanomaterials to deliver potential therapeutics to the targeted site are overwhelming and palpable. Engineering nanomaterials to deliver biological molecules to exert desirable phys...
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Article
Continent-wide evolutionary trends of emerging SARS-CoV-2 variants: dynamic profiles from Alpha to Omicron
The ongoing SARS-CoV-2 evolution process has generated several variants due to its continuous mutations, making pandemics more critical. The present study illustrates SARS-CoV-2 evolution and its emerging muta...
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Article
A comprehensive analysis of the mutational landscape of the newly emerging Omicron (B.1.1.529) variant and comparison of mutations with VOCs and VOIs
The Omicron variant is spreading rapidly throughout several countries. Thus, we comprehensively analyzed Omicron’s mutational landscape and compared mutations with VOC/VOI. We analyzed SNVs throughout the geno...
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Article
Bioengineering of Novel Non-Replicating mRNA (NRM) and Self-Amplifying mRNA (SAM) Vaccine Candidates Against SARS-CoV-2 Using Immunoinformatics Approach
Presently, the world needs safe and effective vaccines to overcome the COVID-19 pandemic. Our work has focused on formulating two types of mRNA vaccines that differ in capacity to copy themselves inside the ce...
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Article
Omicron variant (B.1.1.529) of SARS-CoV-2: understanding mutations in the genome, S-glycoprotein, and antibody-binding regions
The Omicron variant has been detected in nearly 150 countries. We analyzed the mutational landscape of Omicron throughout the genome, focusing the S-glycoprotein. We also evaluated mutations in the antibody-bi...
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Chapter
Challenges of Long Non Coding RNAs in Human Disease Diagnosis and Therapies: Bio-Computational Approaches
Long non-coding RNAs (lncRNAs) are the diverse and prevalent classes of cellular transcripts. Currently numerous research advocates that lncRNAs are the fundamental regulatory elements exist at each level of c...
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Chapter
Therapeutic Applications of CRISPR/Cas9 Technology for Infectious Diseases
The concept of genome alteration in both plant and animal kingdom has come a long way and has transformed medicinal research in the modern era. The predetermined gene expression may be modulated (i.e., upregul...
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Article
Lessons Learned from Cutting-Edge Immunoinformatics on Next-Generation COVID-19 Vaccine Research
Presently, immunoinformatics and bioinformatics approaches are contributing actively to COVID-19 vaccine research. The first immunoinformatics-based vaccine construct against SARS-CoV-2 was published in Februa...
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Article
Safety and feasibility of single-incision laparoscopic totally extraperitoneal inguinal hernia repair: a retrospective comparative analysis of 163 patients
To analyze the benefit and feasibility of single-incisional laparoscopic totally extraperitoneal (SIL TEP) repair compared with those of conventional laparoscopic TEP (CL TEP).
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Article
D614G mutation and SARS-CoV-2: impact on S-protein structure, function, infectivity, and immunity
The progression of the COVID-19 pandemic has generated numerous emerging variants of SARS-CoV-2 on a global scale. These variants have gained evolutionary advantages, comprising high virulence and serious infe...
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Article
Evaluation and Designing of Epitopic-Peptide Vaccine Against Bunyamwera orthobunyavirus Using M-Polyprotein Target Sequences
Bunyamwera orthobunyavirus and its serogroup can cause several diseases in humans, cattle, ruminants, and birds. The viral M-polyprotein helps the virus to enter the host body. Therefore, this protein might serve...
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Article
Understanding the molecular evolution of tiger diversity through DNA barcoding marker ND4 and NADH dehydrogenase complex using computational biology
Currently, Tigers (the top predator of an ecosystem) are on the list of endangered species. Thus the need is to understand the tiger's population genomics to design their conservation strategies.
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Article
Open AccessDetermination of k-mer density in a DNA sequence and subsequent cluster formation algorithm based on the application of electronic filter
We describe a novel algorithm for information recovery from DNA sequences by using a digital filter. This work proposes a three-part algorithm to decide the k-mer or q-gram word density. Employing a finite imp...
