10 Result(s)
within
Arvin Iracheta-Vellve
English
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Article
Open AccessThe PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity
Immune checkpoint blockade is effective for some patients with cancer, but most are refractory to current immunotherapies and new approaches are needed to overcome resistance1,2. The protein tyrosine phosphatases...
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Targeting TBK1 to overcome resistance to cancer immunotherapy
Despite the success of PD-1 blockade in melanoma and other cancers, effective treatment strategies to overcome resistance to cancer immunotherapy are lacking1,2. Here we identify the innate immune kinase TANK-bin...
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Article
In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer
The immune system can eliminate tumors, but checkpoints enable immune escape. Here, we identify immune evasion mechanisms using genome-scale in vivo CRISPR screens across cancer models treated with immune chec...
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Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity
Epigenetic dysregulation is a defining feature of tumorigenesis that is implicated in immune escape1,2. Here, to identify factors that modulate the immune sensitivity of cancer cells, we performed in vivo CRISPR–...
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Open AccessChronic alcohol-induced neuroinflammation involves CCR2/5-dependent peripheral macrophage infiltration and microglia alterations
Chronic alcohol consumption is associated with neuroinflammation, neuronal damage, and behavioral alterations including addiction. Alcohol-induced neuroinflammation is characterized by increased expression of ...
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Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade
Most patients with cancer either do not respond to immune checkpoint blockade or develop resistance to it, often because of acquired mutations that impair antigen presentation. Here we show that loss of functi...
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Open AccessReduced gut microbiome protects from alcohol-induced neuroinflammation and alters intestinal and brain inflammasome expression
The end-organ effects of alcohol span throughout the entire body, from the gastrointestinal tract to the central nervous system (CNS). In the intestine, alcohol use changes the microbiome composition and incre...
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IL-1α in acetaminophen toxicity: a sterile danger signal
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Modulation of cellular stress response via the erythropoietin/CD131 heteroreceptor complex in mouse mesenchymal-derived cells
Tissue-protective properties of erythropoietin (EPO) have let to the discovery of an alternative EPO signaling via an EPO-R/CD131 receptor complex which can now be specifically targeted through pharmaceuticall...
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Gap junction inhibition prevents drug-induced liver toxicity and fulminant hepatic failure
Liver toxicity is one of the most common reasons for abandoning new drugs in development or withdrawing approved drugs from the market. Patel et al. show that in mice drug-induced liver injury can be limited by s...
