11 Result(s)
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Article
A Therapeutic Target for Hormone-independent Estrogen Receptor-positive Breast Cancers
The action of the steroid hormone estradiol (E2) is mediated via interaction with a specific receptor (ER) that initiates a series of events downstream, leading to the modulation of hormone-responsive genes an...
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Article
Potent Induction of Apoptosis by β-Lapachone in Human Multiple Myeloma Cell Lines and Patient Cells
Human multiple myeloma (MM) remains an incurable hematological malignancy. We have reported that β-lapachone, a pure compound derived from a plant, can induce cell death in a variety of human carcinoma cells, inc...
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Article
Suberoylanilide Hydroxamic Acid as a Potential Therapeutic Agent for Human Breast Cancer Treatment
Suberoylanilide hydroxamic acid (SAHA) is a prototype of the newly developed, second-generation, hybrid polar compounds. It is a novel histone deacetylase inhibitor with high potency for inducing cell differen...
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Article
β-Lapachone Induces Cell Cycle Arrest and Apoptosis in Human Colon Cancer Cells
Human colon cancers have a high frequency of p53 mutations, and cancer cells expressing mutant p53 tend to be resistant to current chemo- and radiation therapy. It is thus important to find therapeutic agents ...
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Article
A Strategy to Identify Genes Associated with Circulating Solid Tumor Cell Survival in Peripheral Blood
Efforts in metastasis research have centered on the phenotypic and genetic differences between primary site and metastatic site tumors. However, genes that may be used as molecular markers of metastasis in cir...
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Article
Release of Mitochondrial Cytochrome C in Both Apoptosis and Necrosis Induced by β-Lapachone in Human Carcinoma Cells
There are two fundamental forms of cell death: apoptosis and necrosis. Molecular studies of cell death thus far favor a model in which apoptosis and necrosis share very few molecular regulators. It appears tha...
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Article
Down-Regulation of Laminin-5 in Breast Carcinoma Cells
Laminin-5 (ln-5), a large heterotrimeric glycoprotein consisting of an α3, β3, and γ2 chain, is a component of epithelial cell basement membranes that functions as a ligand of the α3βl and α6β4 integrins to regul...
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Article
Classification of Breast Cancer Cells on the Basis of a Functional Assay for Estrogen Receptor
The receptor (ER) for estrogen (E2) is routinely assayed as a marker to determine the feasibility of anti-hormone therapy against breast cancer because ER-positive (ER+) tumors are much more likely to respond ...
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Article
Identification of mRNAs Differentially Expressed in Quiescence or in Late G1 Phase of the Cell Cycle in Human Breast Cancer Cells by Using the Differential Display Method
The decision for a cell to enter the DNA synthesis (S) phase of the cell cycle or to arrest in quiescence is likely to be determined by genes expressed in the late G1 phase, at the restriction point. Loss of r...
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Article
Cyclin E — a better prognostic marker for breast cancer than cyclin D?
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Article
Pentoxifylline and Other Protein Kinase C Inhibitors Down-Regulate HIV-LTR NF-κB Induced Gene Expression
This investigation deals with the molecular mechanism of anti-human immunodeficiency virus type 1 (HIV-1) action of pentoxifylline (PTX) [1-(5′-oxohexyl)-3,7-dimethylxanthine] a drug widely used for the treatm...
