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  1. Article

    Open Access

    Population-specific causal disease effect sizes in functionally important regions impacted by selection

    Many diseases exhibit population-specific causal effect sizes with trans-ethnic genetic correlations significantly less than 1, limiting trans-ethnic polygenic risk prediction. We develop a new method, S-LDXR,...

    Huwenbo Shi, Steven Gazal, Masahiro Kanai, Evan M. Koch… in Nature Communications (2021)

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  2. No Access

    Article

    Functionally informed fine-map** and polygenic localization of complex trait heritability

    Fine-map** aims to identify causal variants impacting complex traits. We propose PolyFun, a computationally scalable framework to improve fine-map** accuracy by leveraging functional annotations across the...

    Omer Weissbrod, Farhad Hormozdiari, Christian Benner, Ran Cui… in Nature Genetics (2020)

  3. Article

    Open Access

    Quantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection

    Understanding the role of rare variants is important in elucidating the genetic basis of human disease. Negative selection can cause rare variants to have larger per-allele effect sizes than common variants. H...

    Armin P. Schoech, Daniel M. Jordan, Po-Ru Loh, Steven Gazal… in Nature Communications (2019)

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  4. No Access

    Article

    Mixed-model association for biobank-scale datasets

    Po-Ru Loh, Gleb Kichaev, Steven Gazal, Armin P. Schoech, Alkes L. Price in Nature Genetics (2018)