6 Result(s)

Article

Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes

Metabolic syndrome is characterized by disturbances in glucose homeostasis and the development of low-grade systemic inflammation, which increase the risk to develop type 2 diabetes mellitus (T2DM). Type-2 inn...

Lauriane Galle-Treger, Ishwarya Sankaranarayanan… in Nature Communications (2019)

Article

A CRISPR-Cas9 delivery system for in vivo screening of genes in the immune system

Therapies that target the function of immune cells have significant clinical efficacy in diseases such as cancer and autoimmunity. Although functional genomics has accelerated therapeutic target discovery in c...

Martin W. LaFleur, Thao H. Nguyen, Matthew A. Coxe… in Nature Communications (2019)

Article

PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity

Allergic asthma is a leading chronic disease associated with airway hyperreactivity (AHR). Type-2 innate lymphoid cells (ILC2s) are a potent source of T-helper 2 (Th2) cytokines that promote AHR and lung infla...

Doumet Georges Helou, Pedram Shafiei-Jahani, Richard Lo… in Nature Communications (2020)

Article

Gata6⁺ resident peritoneal macrophages promote the growth of liver metastasis

Emerging evidence suggests that resident macrophages within tissues are enablers of tumor growth. However, a second population of resident macrophages surrounds all visceral organs within the cavities and noth...

Mokarram Hossain, Raymond Shim, Woo-Yong Lee, Arlene H. Sharpe… in Nature Communications (2022)

Article

PD-L2 controls peripherally induced regulatory T cells by maintaining metabolic activity and Foxp3 stability

Regulatory T (Treg) cells are central to limit immune responses to allergens. Here we show that PD-L2 deficiency prevents the induction of tolerance to ovalbumin and control of airway hyperreactivity, in parti...

Benjamin P. Hurrell, Doumet Georges Helou, Emily Howard… in Nature Communications (2022)

Article

Publisher Correction: Targeting PD-L2–RGMb overcomes microbiome-related immunotherapy resistance

Joon Seok Park, Francesca S. Gazzaniga, Meng Wu, Amalia K. Luthens, Jacob Gillis… in Nature (2023)