42 Result(s)
within
Arlene H Sharpe
Biomedicine
English
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Article
Editorial Expression of Concern: The threshold pattern of calcineurin-dependent gene expression is altered by loss of the endogenous inhibitor calcipressin
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Article
X-CHIME enables combinatorial, inducible, lineage-specific and sequential knockout of genes in the immune system
Annotation of immunologic gene function in vivo typically requires the generation of knockout mice, which is time consuming and low throughput. We previously developed CHimeric IMmune Editing (CHIME), a CRISPR...
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Article
Open AccessMicrobiota-dependent regulation of costimulatory and coinhibitory pathways via innate immune sensors and implications for immunotherapy
Our bodies are inhabited by trillions of microorganisms. The host immune system constantly interacts with the microbiota in barrier organs, including the intestines. Over decades, numerous studies have shown t...
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Article
PD-L1–PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection
Phenotypic and transcriptional profiling of regulatory T (Treg) cells at homeostasis reveals that T cell receptor activation promotes Treg cells with an effector phenotype (eTreg) characterized by the production ...
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Article
Repertoire analyses reveal T cell antigen receptor sequence features that influence T cell fate
T cells acquire a regulatory phenotype when their T cell antigen receptors (TCRs) experience an intermediate- to high-affinity interaction with a self-peptide presented via the major histocompatibility complex...
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Not-so-opposite ends of the spectrum: CD8+ T cell dysfunction across chronic infection, cancer and autoimmunity
CD8+ T cells are critical mediators of cytotoxic effector function in infection, cancer and autoimmunity. In cancer and chronic viral infection, CD8+ T cells undergo a progressive loss of cytokine production and ...
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Article
Interplay of somatic alterations and immune infiltration modulates response to PD-1 blockade in advanced clear cell renal cell carcinoma
PD-1 blockade has transformed the management of advanced clear cell renal cell carcinoma (ccRCC), but the drivers and resistors of the PD-1 response remain incompletely elucidated. Here, we analyzed 592 tumors...
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Prevention of CAR-T-cell dysfunction
The overexpression of the transcription factor c-Jun improves chimeric-antigen-receptor T-cell functionality and enhances the killing of low-antigen-expressing liquid and solid cancers in mice.
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Fibroblastic reticular cells enhance T cell metabolism and survival via epigenetic remodeling
Lymph node fibroblastic reticular cells (FRCs) respond to signals from activated T cells by releasing nitric oxide, which inhibits T cell proliferation and restricts the size of the expanding T cell pool. Whet...
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Article
Author Correction: Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Defining ‘T cell exhaustion’
‘T cell exhaustion’ is a broad term that has been used to describe the response of T cells to chronic antigen stimulation, first in the setting of chronic viral infection but more recently in response to tumou...
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Article
Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses
Follicular regulatory T (TFR) cells have specialized roles in modulating follicular helper T (TFH) cell activation of B cells. However, the precise role of TFR cells in controlling antibody responses to foreign a...
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Article
PTPN2 regulates the generation of exhausted CD8+ T cell subpopulations and restrains tumor immunity
CD8+ T cell exhaustion is a state of dysfunction acquired in chronic viral infection and cancer, characterized by the formation of Slamf6+ progenitor exhausted and Tim-3+ terminally exhausted subpopulations throu...
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Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade
T cell dysfunction is a hallmark of many cancers, but the basis for T cell dysfunction and the mechanisms by which antibody blockade of the inhibitory receptor PD-1 (anti-PD-1) reinvigorates T cells are not fu...
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The diverse functions of the PD1 inhibitory pathway
Programmed cell death protein 1 (PD1) is an inhibitory receptor that is expressed by all T cells during activation. It regulates T cell effector functions duri...
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Article
Erratum: The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection
Nat. Immunol.; doi:10.1038/ni.3755; corrected online 2 June 2017 In the version of this article initially published online, the symbols in the key for Figure 2a were reversed. The correct key symbol colors are...
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Article
The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection
Wucherpfennig and colleagues show that the microRNA miR-31 increases the sensitivity of T cells to type I interferons, which interferes with effector T cell function during chronic infection.
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Article
Suppression by TFR cells leads to durable and selective inhibition of B cell effector function
Follicular regulatory T cells (TFR cells) inhibit follicular helper T cell (TFH cell)-mediated antibody production. Sharpe and colleagues show that TFR cells induce a distinct suppressive state in TFH cells and B...
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Enhancing the Efficacy of Checkpoint Blockade Through Combination Therapies
Antibodies targeting coinhibitory receptors on T cells (“checkpoint blockade”) have emerged as some of the most promising therapies for a broad range of malignancies, including melanoma, non-small cell lung ca...
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Article
Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability
Regulatory T cells normally maintain high expression of the phosphatase PTEN. Turka and colleagues use conditional deletion of PTEN in regulatory T cells to show that it is critical for their function and stab...
