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  1. No Access

    Article

    Sequential cancer mutations in cultured human intestinal stem cells

    Crypt stem cells represent the cells of origin for intestinal neoplasia. Both mouse and human intestinal stem cells can be cultured in medium containing the stem-cell-niche factors WNT, R-spondin, epidermal gr...

    Jarno Drost, Richard H. van Jaarsveld, Bas Ponsioen, Cheryl Zimberlin… in Nature (2015)

  2. Article

    Open Access

    Both SEPT2 and MLL are down-regulated in MLL-SEPT2therapy-related myeloid neoplasia

    A relevant role of septins in leukemogenesis has been uncovered by their involvement as fusion partners in MLL-related leukemia. Recently, we have established the MLL-SEPT2 gene fusion as the molecular abnormalit...

    Nuno Cerveira, Joana Santos, Susana Bizarro, Vera Costa, Franclim R Ribeiro… in BMC Cancer (2009)

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    Article

    The MN1 oncoprotein synergizes with coactivators RAC3 and p300 in RAR-RXR-mediated transcription

    The t(12;22) creates an MN1–TEL fusion gene leading to acute myeloid leukemia. The fusion partner TEL (ETV6) is a member of the ETS family of transcription factors. The nature of the other fusion partner, MN1, ha...

    Karel H M van Wely, Anco C Molijn, Arjan Buijs, Magda A Meester-Smoor… in Oncogene (2003)