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  1. Article

    Open Access

    Serum protein profiling reveals an inflammation signature as a predictor of early breast cancer survival

    Breast cancers exhibit considerable heterogeneity in their biology, immunology, and prognosis. Currently, no validated, serum protein-based tools are available to evaluate the prognosis of patients with early ...

    Peeter Karihtala, Suvi-Katri Leivonen, Ulla Puistola in Breast Cancer Research (2024)

  2. Article

    Open Access

    Neuropilin-1 and placental growth factor as prognostic factors in metastatic breast cancer

    Angiogenesis is crucial for tumor development, progression, and metastasizing. The most important regulator of angiogenesis is the vascular endothelial growth factor (VEGF) family, which is involved in multipl...

    Niina Mäenpää, Leena Tiainen, Mari Hämäläinen, Tiina Luukkaala, Minna Tanner in BMC Cancer (2024)

  3. Article

    Open Access

    Previous radiotherapy improves treatment responses and causes a trend toward longer time to progression among patients with immune checkpoint inhibitor-related adverse events

    Immune-related adverse events (irAEs) are frequently encountered by patients during immune checkpoint inhibitor (ICI) treatment and are associated with better treatment outcomes. The sequencing of radiotherapy...

    Anna Jokimäki, Henna Hietala, Jasmiini Lemma in Cancer Immunology, Immunotherapy (2023)

  4. Article

    Open Access

    High baseline Tie1 level predicts poor survival in metastatic breast cancer

    Angiopoietin growth factors (Angs) regulate angiogenesis and lymphangiogenesis by binding to the endothelial Tie2 receptor. Ang2 expression is elevated in tissue hypoxia and inflammation, which also induce cle...

    Leena Tiainen, Emilia A. Korhonen, Veli-Matti Leppänen, Tiina Luukkaala in BMC Cancer (2019)

  5. No Access

    Article

    Increased risk of certain second primary malignancies in patients treated for well-differentiated thyroid cancer

    The objective was to evaluate the incidence of second primary malignancies (SPMs) in thyroid cancer patients compared to age- and gender-matched controls without thyroid cancer from the general population of ...

    Tommi T. Hakala, Juhani A. Sand, Arja Jukkola in International Journal of Clinical Oncology (2016)