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Article
Open AccessTranscriptional immunogenomic analysis reveals distinct immunological clusters in paediatric nervous system tumours
Cancer immunotherapies including immune checkpoint inhibitors and Chimeric Antigen Receptor (CAR) T-cell therapy have shown variable response rates in paediatric patients highlighting the need to establish rob...
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Article
Open AccessMultimodal immunogenomic biomarker analysis of tumors from pediatric patients enrolled to a phase 1-2 study of single-agent atezolizumab
We report herein an exploratory biomarker analysis of refractory tumors collected from pediatric patients before atezolizumab therapy (iMATRIX-atezolizumab, NCT02541604
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Article
Open AccessGenomic predictors of response to PD-1 inhibition in children with germline DNA replication repair deficiency
Cancers arising from germline DNA mismatch repair deficiency or polymerase proofreading deficiency (MMRD and PPD) in children harbour the highest mutational and microsatellite insertion–deletion (MS-indel) bur...
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Article
Molecular characteristics and therapeutic vulnerabilities across paediatric solid tumours
The spectrum of tumours arising in childhood is fundamentally different from that seen in adults, and they are known to be divergent from adult malignancies in terms of cellular origins, epidemiology, genetic ...
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Article
Molecular mechanism of the TP53-MDM2-AR-AKT signalling network regulation by USP12
The TP53-MDM2-AR-AKT signalling network plays a critical role in the development and progression of prostate cancer. However, the molecular mechanisms regulating this signalling network are not completely defi...
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Article
Open AccessHuman ex vivo prostate tissue model system identifies ING3 as an oncoprotein
Although the founding members of the INhibitor of Growth (ING) family of histone mark readers, ING1 and ING2, were defined as tumour suppressors in animal models, the role of other ING proteins in cellular pro...
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Article
Open AccessING3 promotes prostate cancer growth by activating the androgen receptor
The androgen receptor (AR) is a major driver of prostate cancer, and increased AR levels and co-activators of the receptor promote the development of prostate cancer. INhibitor of Growth (ING) proteins target ...
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Article
ING3 is associated with increased cell invasion and lethal outcome in ERG-negative prostate cancer patients
The inhibitor of growth family member 3 (ING3) is a member of the ING tumor suppressor family. Although its expression has been reported in various types of cancers, the role of ING3 and its prognostic value i...
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Article
Open AccessStromal ING1 expression induces a secretory phenotype and correlates with breast cancer patient survival
Previous studies have established that levels of the Inhibitor of Growth 1(ING1) tumor suppressor are reduced in a significant proportion of different cancer types. Here we analyzed levels of ING1 in breast ca...
