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Article
Open AccessRecurrence Rates and Pharmacological Treatment for Hemorrhoidal Disease: A Systematic Review
Hemorrhoidal disease (HD) is characterized by prolapse of the inflamed and bleeding vascular tissues of the anal canal. Although HD is associated with a high recurrence rate, there is a lack of understanding a...
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Article
Laser ablation of anal fistulae: a 6-year experience in a tertiary teaching hospital in Malaysia
Several studies have investigated the role of laser ablation of anal fistulae in the European setting. However, long-term follow-up results following laser fistula ablations are not widely investigated and no ...
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Article
Open AccessComparison of post-operative bleeding incidence in laser hemorrhoidoplasty with and without hemorrhoidal artery ligation: a double-blinded randomized controlled trial
The effectiveness of hemorrhoidal artery ligation supplementation in reducing the incidence of post laser hemorrhoidoplasty bleeding has not been investigated.
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Article
Pathological Complete Response After Neoadjuvant Therapy in Rectal Adenocarcinoma: a 5-Year Follow-up
Neoadjuvant therapy is the gold standard treatment of locally advanced rectal cancer. It may induce complete sterilization of tumor cell and decreases its local recurrence rate. While 15–20% of patients were f...
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Article
Open AccessLMTK3 confers chemo-resistance in breast cancer
Lemur tyrosine kinase 3 (LMTK3) is an oncogenic kinase that is involved in different types of cancer (breast, lung, gastric, colorectal) and biological processes including proliferation, invasion, migration, c...
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Article
Open AccessSurvival rates and predictors of survival among colorectal cancer patients in a Malaysian tertiary hospital
Colorectal cancer is the third most commonly diagnosed malignancy and the fourth leading cause of cancer-related death globally. It is the second most common cancer among both males and females in Malaysia. Th...
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Article
Heterogeneity in cancer cells: variation in drug response in different primary and secondary colorectal cancer cell lines in vitro
Tumor heterogeneity may give rise to differential responses to chemotherapy drugs. Therefore, unraveling tumor heterogeneity has an implication for biomarker discovery and cancer therapeutics. To test this phe...
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Article
Financial burden of colorectal cancer treatment among patients and their families in a middle-income country
In Malaysia, the healthcare system consists of a government-run universal healthcare system and a co-existing private healthcare system. However, with high and ever rising healthcare spending on cancer managem...
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Article
Pre-surgical Administration of Microbial Cell Preparation in Colorectal Cancer Patients: A Randomized Controlled Trial
Disruption of normal gut function is a common side effect post abdominal surgery. It may result in reduced tolerance to oral nutrition and progress to postoperative ileus. Microbial cell preparation is benefic...
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Article
The perceived cancer-related financial hardship among patients and their families: a systematic review
The escalating health-care spending for cancer management has caused cancer patients to struggle further as a result of financial burden. This systematic review was carried out to investigate the prevalence of...
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Article
Culture of low passage colorectal cancer cells and demonstration of variation in selected tumour marker expression
There is increasing evidence that a tumour comprises of heterogeneous population of cells. Thus, studying homogenous cell lines in vitro may yield results that are not reflective of the true situation in a tum...
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Article
Open AccessAdvantage of using colonic washouts for Blastocystis detection in colorectal cancer patients
There have been previous studies associating microorganisms to cancer and with our recent findings of Blastocytsis antigen having a higher in vitro proliferation of cancer cells strengthens the suspicion. Collect...
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Article
Open AccessHealth-related quality of life among colorectal cancer patients in Malaysia: a study protocol
Colorectal cancer is a major public health problem in Malaysia. However, it is also one of the most treatable cancers, resulting in significant numbers of survivors. Therefore, the impact of surviving treatmen...