13 Result(s)
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Antonio R. Lucena-Araujo
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Article
Open AccessPrognostic implications of ΔNp73/TAp73 expression ratio in core-binding factor acute myeloid leukemia
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The ratio of ATP11C/PLSCR1 mRNA transcripts has clinical significance in sickle cell anemia
One of the physiologic mechanisms responsible to maintain asymmetric phospholipid distribution (in particular phosphatidylserine, PS) in human erythrocyte membranes is orchestrated by the balance between enzym...
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Article
Association of KLOTHO polymorphisms with clinical complications of sickle cell anemia
The clinical and phenotypic heterogeneity of patients with sickle cell anemia (SCA) is influenced by environmental and genetic factors. Several genetic modifiers, such as the KLOTHO (KL) gene, have been associate...
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Open AccessMLL5 improves ATRA driven differentiation and promotes xenotransplant engraftment in acute promyelocytic leukemia model
Although the mixed lineage leukemia 5 (MLL5) gene has prognostic implications in acute promyelocyte leukemia (APL), the underlying mechanism remains to be elucidated. Here, we demonstrate the critical role exerte...
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Influence of UGT1A1 promoter polymorphism, α-thalassemia and βs haplotype in bilirubin levels and cholelithiasis in a large sickle cell anemia cohort
Hyperbilirubinemia in patients with sickle cell anemia (SCA) as a result of enhanced erythrocyte destruction, lead to cholelithiasis development in a subset of patients. Evidence suggests that hyperbilirubinem...
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Open AccessMolecular-Based Score inspired on metabolic signature improves prognostic stratification for myelodysplastic syndrome
Deregulated cellular energetics is formally incorporated as an emerging hallmark of cancer, however little is known about its processes in myelodysplastic syndromes (MDS). Using transcriptomic data of CD34+ ce...
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High levels of proinflammatory cytokines IL-6 and IL-8 are associated with a poor clinical outcome in sickle cell anemia
Sickle cell anemia (SCA) pathophysiology is characterized by the activation of sickle red blood cells, reticulocytes, leukocytes, platelets, and endothelial cells, and with the expression of several inflammato...
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Open AccessPersistent detection of Zika virus RNA from an infant with severe microcephaly – a case report
Zika virus (ZIKV) is a recently emerged arbovirus, which infection during pregnancy is associated with a series of congenital malformations, collectively denominated Congenital Zika Syndrome (CZS). Following i...
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Internal tandem duplication of the FLT3 gene confers poor overall survival in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline-based chemotherapy: an International Consortium on Acute Promyelocytic Leukemia study
Activating internal tandem duplication (ITD) mutations in the fms-like tyrosine kinase 3 (FLT3) gene (FLT3-ITD) are associated with poor outcome in acute myeloid leukemia, but their prognostic impact in acute pro...
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Article
Influence of the βs haplotype and α-thalassemia on stroke development in a Brazilian population with sickle cell anaemia
Stroke is a catastrophic complication of sickle cell anaemia (SCA) and is one of the leading causes of death in both adults and children with SCA. Evidence suggests that some genetic polymorphisms could be rel...
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Article
Open AccessIncreased expression of miR-221 is associated with shorter overall survival in T-cell acute lymphoid leukemia
CD56 expression has been associated with a poor prognosis in lymphoid neoplasms, including T-cell acute lymphoblastic leukemia (T-ALL). MicroRNAs (miRNAs) play an important role in lymphoid differentiation, an...
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Erratum to: Results of FLT3 mutation screening and correlations with immunophenoty** in 169 Brazilian patients with acute myeloid leukemia
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Article
Results of FLT3 mutation screening and correlations with immunophenoty** in 169 Brazilian patients with acute myeloid leukemia
