7 Result(s)
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Article
Open AccessThe effect of dosage on the protective efficacy of whole-sporozoite formulations for immunization against malaria
Immunization with Plasmodium sporozoites, either attenuated or administered under the cover of an antimalarial drug, can induce strong protection against malaria in pre-clinical murine models, as well as in human...
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Article
Open AccessA genetically modified Plasmodium berghei parasite as a surrogate for whole-sporozoite vaccination against P. vivax malaria
Two malaria parasite species, Plasmodium falciparum (Pf) and P. vivax (Pv) are responsible for most of the disease burden caused by malaria. Vaccine development against this disease has focused mainly on Pf. Whol...
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Article
Open AccessCreation and preclinical evaluation of genetically attenuated malaria parasites arresting growth late in the liver
Whole-sporozoite (WSp) malaria vaccines induce protective immune responses in animal malaria models and in humans. A recent clinical trial with a WSp vaccine comprising genetically attenuated parasites (GAP) w...
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Article
Open AccessInhibition of Plasmodium sporogonic stages by ivermectin and other avermectins
The transmissible forms of Plasmodium parasites result from a process of sporogony that takes place inside their obligatory mosquito vector and culminates in the formation of mammalian-infective parasite forms. I...
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Article
Open AccessPre-clinical evaluation of a P. berghei-based whole-sporozoite malaria vaccine candidate
Whole-sporozoite vaccination/immunization induces high levels of protective immunity in both rodent models of malaria and in humans. Recently, we generated a transgenic line of the rodent malaria parasite P. berg...
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Open AccessA Plasmodium berghei sporozoite-based vaccination platform against human malaria
There is a pressing need for safe and highly effective Plasmodium falciparum (Pf) malaria vaccines. The circumsporozoite protein (CS), expressed on sporozoites and during early hepatic stages, is a leading target...
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Whole-Sporozoite Malaria Vaccines
Whole-sporozoite administration is the sole immunization strategy that has been shown to elicit sterile immunity against malaria. Sporozoite-based immunization aims at eliciting potent pre-erythrocytic immune ...
