16 Result(s)
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Antonio Giovanni Solimando
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Article
Open AccessComprehensive analysis of clinical outcomes, infectious complications and microbiological data in newly diagnosed multiple myeloma patients: a retrospective observational study of 92 subjects
Patients with multiple myeloma (MM) have an increased risk of sepsis due to underlying disease- and treatment-related immunosuppression. However, data on sepsis incidence, causative pathogens, and impact on ou...
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Article
Open AccessImmune escape of multiple myeloma cells results from low miR29b and the ensuing epigenetic silencing of proteasome genes
Activation of CD28 on multiple myeloma (MM) plasma cells, by binding to CD80 and CD86 on dendritic cells, decreases proteasome subunit expression in the tumor cells and thereby helps them evade being killed by...
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Article
Open AccessSTAT1 overexpression triggers aplastic anemia: a pilot study unravelling novel pathogenetic insights in bone marrow failure
We identified STAT1 gain of function (GOF) in a 32-year-old female with pallor, weakness, cough, and dyspnea admitted to our Division of Medicine. She had severe oral ulcers (OU), type 1 diabetes (T1DM), and p...
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Article
Open AccessImmune disturbance leads to pulmonary embolism in COVID-19 more than classical risk factors: a clinical and histological study
COVID-19 induces endotheliitis and one of the main complications is enhanced coagulation. The incidence of pulmonary embolism (PE) in COVID-19 (CPE) has increased and clinical features for a rigorous analysis ...
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Chapter and Conference Paper
Block of the Angiotensin Pathways Affects Flow-Volume Spirometry in Patients with SARS-CoV-2 Infection
Background: Angiotensin Converting Enzyme 2 (ACE2) is an endothelial cell receptor used by SARS-CoV- 2 virus to enter cells. Pulmonary function tests (PFTs), mainly spirometry, are the main diagnostic tools for m...
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Chapter
The Role of Pericytes in Tumor Angiogenesis
Pericytes are branched cells surrounded by the basement membrane (BM) of capillaries and post-capillary venules. Pericytes are involved in the control of endothelial cell proliferation, migration, and stabiliz...
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Article
Highlights in clinical medicine—Giant cell arteritis, polymyalgia rheumatica and Takayasu’s arteritis: pathogenic links and therapeutic implications
Giant cell arteritis (GCA), frequently associated with polymyalgia rheumatica (PMR), and Takayasu’s arteritis (TAK) are characterized by extensive vascular remodeling that results in occlusion and stenosis. Th...
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Article
Open AccessIntegrated lung ultrasound score for early clinical decision-making in patients with COVID-19: results and implications
Lung Ultrasound Score (LUS) identifies and monitors pneumonia by assigning increasing scores. However, it does not include parameters, such as inferior vena cava (IVC) diameter and index of collapse, diaphragm...
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Article
Open AccessSecond-line treatments for Advanced Hepatocellular Carcinoma: A Systematic Review and Bayesian Network Meta-analysis
A plethora of second-line therapies have been recently introduced for hepatocellular carcinoma (HCC) treatment with promising results. A meta-analysis of second-line treatments for HCC has been performed to be...
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Article
Open AccessPrognostic role of neoplastic markers in Takotsubo syndrome
Takotsubo syndrome (TTS) is an acute heart failure syndrome with significant rates of in and out-of-hospital mayor cardiac adverse events (MACE). To evaluate the possible role of neoplastic biomarkers [CA-15.3...
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Article
BL1391: an established cell line from a human malignant peripheral nerve sheath tumor with unique genomic features
Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive tumors, accounting for around 5% of all soft tissue sarcomas. A better understanding of the pathogenesis of these tumors and the development of ...
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Chapter
Hepatocellular Cancer
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer in adults, and currently it still remains third leading cause of cancer death.
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Article
Open AccessCorrection to: Liquid biopsy and tumor heterogeneity in metastatic solid tumors: the potentiality of blood samples
An amendment to this paper has been published and can be accessed via the original article.
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Article
Open AccessLiquid biopsy and tumor heterogeneity in metastatic solid tumors: the potentiality of blood samples
In a large number of cancer types, treatment selection depends on the presence of specific tumor biomarkers. Due to the dynamic nature of cancer, very often these predictive biomarkers are not uniformly presen...
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Article
Early echocardiographic detection of left ventricular diastolic dysfunction in patients with systemic lupus erythematosus asymptomatic for cardiovascular disease
Cardiovascular disease (CVD) is a major complication of systemic lupus erythematosus (SLE) and is now a leading cause of death for these patients. In this study, 23 SLE patients asymptomatic for CVD underwent ...
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Article
Rhu-Epo down-regulates pro-tumorigenic activity of cancer-associated fibroblasts in multiple myeloma
We have previously demonstrated that recombinant human erythropoietin (rHuEpo) is involved in the regulation of the angiogenic response in multiple myeloma (MM) through a direct effect on macrophages and endot...
