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Article
CHOLANGIOPATHY AND HEPATOBILIARY CANCER IN X-LINKED IMMUNODEFICIENCY WITH HYPER-IGM (XHIM). • 55
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Article
Frequency and Cytokine Phenotype of Blood T Cells from Premature Infants Responding to Staphylococcal Enterotoxin B
ABSTRACT: The responder cell frequency (RCF) of premature (<1900 g birth weight) infants' blood lymphocytes, which proliferate in cultures stimulated by staphylococcal enterotoxin B, falls from 1:3400 to about...
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Article
Herpes Simplex Virus-Stimulated γ-Interferon Production by Newborn Mononuclear Cells
ABSTRACT. Blood mononuclear cells from newborns and from adults, immune or nonimmune to herpes simplex virus, were cultured with IL 2 and herpes simplex virus and the amount of γ-interferon in the supernatant ...
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Article
Response of Human Newborn Lymphocytes to Alloantigen: Lack of Evidence for Suppression Induction
Summary: Between 1:120 and 1:180 of human newborn T cells proliferate in limiting dilution cultures with allogeneic lymphocytes or with la-bearing monocytic stimulator cells. The proliferating responder cells ...
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Article
AN ENZYME-LINKED IMMUNOSORBANT ASSAY FOR ANTIHERPES HERPES SIMPLEX VIRUS (HSV) AND ANTI-VARICELLA ZOSTER VIRUS (VZV) ANTIBODY (AB)
The human newborn and immunocompromised host are particularly susceptible to the devastating effects of disseminated VZV and HSV infection. To further investigate the relevant immune parameters, we developed a...
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Article
CELLULAR INTERACTIONS IN THE LYSIS OF VZV INFECTED FIBROBLASTS
Human blood mononuclear cells (MNC) lysed varicella zoster virus (VZV) infected targets in an 18 hour 51Cr release assay at effector:target (E:T) ratios of 50:1 to 10:1. Mean specific lysis at 50:1 E:T was 45% wh...
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Article
926 THE EFFECT OF PHENYTOIN ON IMMUNOGLOBULIN (Ig) PRODUCTION
Patients treated for epilepsy with phenytoin develop a significant fall in serum IgA. We investigated this association because it may be a model for selective IgA deficiency. Phenytoin (20μg/ml) was added to h...
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Article
SUPPRESSION OF PLASMA CELL DIFFERENTIATION BY PRIMED T LYMPHOCYTES
Cord blood T lymphocytes inhibit the division of maternal T cells and can block plasma cell (PC) differentiation of unrelated B cells induced by pokeweed mitogen (PWM). These effects are variable in degree but...