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Article
Chronic varicella-zoster virus ganglionitis—a possible cause of postherpetic neuralgia
Postherpetic neuralgia (PHN) is dermatomal distribution pain that persists for months to years after the resolution of herpes zoster rash. The cause of PHN is unknown. Herein, we report clinical, molecular vir...
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Article
Respiratory Syncytial Virus Infects the Bonnet Monkey, Macaca radiata
The Bonnet monkey model of respiratory syncytial virus (RSV) infection may be a useful nonhuman primate model for studying RSV disease in humans because Bonnet monkeys can predictably be infected to obtain an...
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Article
CHOLANGIOPATHY AND HEPATOBILIARY CANCER IN X-LINKED IMMUNODEFICIENCY WITH HYPER-IGM (XHIM). • 55
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Article
Frequency and Cytokine Phenotype of Blood T Cells from Premature Infants Responding to Staphylococcal Enterotoxin B
ABSTRACT: The responder cell frequency (RCF) of premature (<1900 g birth weight) infants' blood lymphocytes, which proliferate in cultures stimulated by staphylococcal enterotoxin B, falls from 1:3400 to about...
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Chapter
Development of T Cells with Memory Phenotype in Infancy
Studies in mice give a reasonably clear view of the genes in he germline which are rearranged to give the αβ heterodimer of the T cell receptor for antigen. The role of the thymus in modulating the germline re...
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Article
Lymphocyte responses to varicella zoster virus in the elderly
Elderly subjects (age 75–95 years) immune to varicella zoster virus (VZV) were identified by the presence of serum IgG antibody. The frequency of lymphocytes in their blood which proliferated in varicella zost...
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Article
Reduced cellular immunity to varicella zoster virus during treatment for acute lymphoblastic leukemia of childhood:In Vitro studies of possible mechanisms
To determine the effect of antileukemic therapy on preexisting immunity to varicella zoster virus, we studied 20 children with acute lymphoblastic leukemia maintained in complete continuous remission for great...
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Article
Herpes Simplex Virus-Stimulated γ-Interferon Production by Newborn Mononuclear Cells
ABSTRACT. Blood mononuclear cells from newborns and from adults, immune or nonimmune to herpes simplex virus, were cultured with IL 2 and herpes simplex virus and the amount of γ-interferon in the supernatant ...
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Article
Impaired neonatal natural killer-cell activity to herpes simplex virus: Decreased inhibition of viral replication and altered response to lymphokines
Human adult natural killer (NK) cells were recently demonstrated to inhibit herpes simplex virus (HSV) replicationin vitro. In this study we compared the ability of newborn and adult NK cells to inhibit HSV repli...
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Chapter
Immunity Development
The development of immunity occurs during two separate phases. The first takes place during fetal life, in the absence of exogenous antigen stimulus. It is characterized by the production of immune cells (phag...
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Article
Dissociation among Ia antigen expression, accessory cell function, and antigen processing in two acute monoblastic leukemia lines
To better understand the role of Ia antigen expression, accessory cell function, and antigen ingestion in antigen presentation and the initiation of T cell proliferation, we studied these events in two acute m...
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Article
Response of Human Newborn Lymphocytes to Alloantigen: Lack of Evidence for Suppression Induction
Summary: Between 1:120 and 1:180 of human newborn T cells proliferate in limiting dilution cultures with allogeneic lymphocytes or with la-bearing monocytic stimulator cells. The proliferating responder cells ...
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Article
AN ENZYME-LINKED IMMUNOSORBANT ASSAY FOR ANTIHERPES HERPES SIMPLEX VIRUS (HSV) AND ANTI-VARICELLA ZOSTER VIRUS (VZV) ANTIBODY (AB)
The human newborn and immunocompromised host are particularly susceptible to the devastating effects of disseminated VZV and HSV infection. To further investigate the relevant immune parameters, we developed a...
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Article
CELLULAR INTERACTIONS IN THE LYSIS OF VZV INFECTED FIBROBLASTS
Human blood mononuclear cells (MNC) lysed varicella zoster virus (VZV) infected targets in an 18 hour 51Cr release assay at effector:target (E:T) ratios of 50:1 to 10:1. Mean specific lysis at 50:1 E:T was 45% wh...
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Chapter
The Immunology of Breast Milk
Resistance to infection and protection from allergic disorders (or atopy) are probably the most frequently cited immunologic benefits of breast-feeding. In this chapter, some of the immunologic constituents of...
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Article
Presentation of antigen by human newborn monocytes to maternal tetanus toxoid-specific T-cell blasts
The requirement for linked HLA-D antigen recognition for the proliferation of antigen-specific T-cell blasts provides a method for testing antigen presentation of human monocytes. We used maternal tetanus toxo...
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Article
926 THE EFFECT OF PHENYTOIN ON IMMUNOGLOBULIN (Ig) PRODUCTION
Patients treated for epilepsy with phenytoin develop a significant fall in serum IgA. We investigated this association because it may be a model for selective IgA deficiency. Phenytoin (20μg/ml) was added to h...
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Article
SUPPRESSION OF PLASMA CELL DIFFERENTIATION BY PRIMED T LYMPHOCYTES
Cord blood T lymphocytes inhibit the division of maternal T cells and can block plasma cell (PC) differentiation of unrelated B cells induced by pokeweed mitogen (PWM). These effects are variable in degree but...
