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Editorial Expression of Concern: p63 and p73 are required for p53-dependent apoptosis in response to DNA damage
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Open AccessIn-hospital predictors of post-stroke depression for targeted initiation of Selective Serotonin Reuptake Inhibitors (SSRIs)
Although SSRIs are no longer widely prescribed for post-stroke motor recovery, fluoxetine demonstrated beneficial effects on post-stroke depression (PSD). Given the potential side effects of SSRIs, targeted in...
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Article
CF33-hNIS-antiPDL1 virus primes pancreatic ductal adenocarcinoma for enhanced anti-PD-L1 therapy
Immunotherapeutic strategies that combine oncolytic virus (OV) and immune checkpoint inhibitors have the potential to overcome treatment resistance in pancreatic ductal adenocarcinoma (PDAC), one of the least ...
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Article
Coming Together: How Medical Students, Academic Administrators, and Hospital Administrators Approached Student Volunteering During the COVID-19 Pandemic
The COVID-19 pandemic caused dramatic interruptions and shifts to medical education, but students at schools nationwide responded by volunteering to support their physician educators on the frontlines. Relatio...
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Article
A modified uncut Roux-en-Y anastomosis in totally laparoscopic distal gastrectomy: preliminary results and initial experience
To investigate the safety and feasibility of totally laparoscopic uncut Roux-en-Y anastomosis in the distal gastrectomy with D2 dissection for gastric cancer. We also summarized the preliminary experience of t...
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Article
Open AccessAGE-RAGE signal generates a specific NF-κB RelA “barcode” that directs collagen I expression
Advanced glycation end products (AGEs) are sugar-modified biomolecules that accumulate in the body with advancing age and are implicated in the development of multiple age-associated structural and functional ...
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Article
p63 protects the female germ line during meiotic arrest
Whereas the tumour suppressor gene p53 plays a key role in monitoring and maintaining genomic integrity in somatic cells, it is now shown that in oocytes, a p53 family member, p63 (but not p53 itself), is needed ...
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P53, P63, and P73: Internecine Relations?
The discoveries of p63 and p73 as genes related to the vaunted tumor suppressor p53 launched questions that remain largely unanswered, and fuel controversy and debate. Do these homologs behave like p53? Do the...
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Article
p63 and p73 are required for p53-dependent apoptosis in response to DNA damage
The tumour-suppressor gene p53 is frequently mutated in human cancers and is important in the cellular response to DNA damage1,2. Although the p53 family members p63 and p73 are structurally related to p53, they ...
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Article
p63 and p73: p53 mimics, menaces and more
Less than five years ago, the tumour suppressor p53 was thought to be one of a kind, but the discovery of two related gene products, p63 and p73, raised the p...
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Article
p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours
p73 (ref. 1) has high homology with the tumour suppressor p53 (refs 2,3,4), as well as with p63, a gene implicated in the maintenance of epithelial stem cells5,6,7. Despite the localization of the p73 gene to chr...
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Article
p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
The p63 gene, a homologue of the tumour-suppressor p53 (1–5), is highly expressed in the basal or progenitor layers of many epithelial tissues1. Here we report that mice homozygous for a disrupted p63 gene have m...
